卡托普利对糖尿病合并肺结核应用氨基糖甙类药物时肾脏的保护作用

Protective effect of captopril on kidney of diabetic patients with pulmonary tuberculosis by aminoglycoside

目的 观察卡托普利对糖尿病合并肺结核患者应用氨基糖甙类药物时对肾脏的保护作用。方法 85例糖尿病合并肺结核患者 ,随机分为治疗组 ( 44例 )与对照组 ( 41例 )。两组抗痨方案均含氨基糖甙类药物。治疗组在 2个月强化治疗期间加服卡托普利。治疗前及强化治疗结束时检测尿微量白蛋白、β2 —微球蛋白、血清肌酐及肌酐清除率并进行比较。结果 治疗组 β2 -微球蛋白较治疗前显著降低 (P <0 .0 5) ,其余各项指标无明显变化。对照组尿微量白蛋白和 β2 -微球蛋白显著增加 (P <0 .0 1 ,P <0 .0 5)。结论 卡托普利对长期应用氨基糖甙类药物患者的肾脏有一定的保护作用。

Objective To investigate the mechanism of captopril's protecting the kidney of diabetic patients with pulm.Tuberculosis(PTB)by aminoglycoside(AG).Methods 85 diabetic cases with PTB were divided into treating group(44 cases,group A) and control group(41 cases,group B),AG were used in both A and B group,Patients in group A took captopril during treatment.Urinary micro-albumin,β 2-m,serum creatinine and creatinine clearance were measured before and after treatment.Results Urinary β 2-m in group A decreased significantly after tretment than that before treatment(P<0.05),the others had no significant change.But urinary microalbumin and β 2-m in Group B increased significantly(P<0.01 and P<0.05),Conclusion Captopril can reduce the amount of urinary albumin and protect the kidney function on cases of diabetics with PTB.