雌孕激素序贯疗法在青春期功血治疗中的价值研究

目的研究雌孕激素序贯疗法在青春期功血治疗中的应用价值。方法将68例患者随机分成两组,即对照组和实验组,每组34例,实验组采用雌孕激素(安宫黄体酮联合戊酸雌二醇)治疗,对照组采用雌激素(戊酸雌二醇)治疗,治疗止血20d后比较两组患者的临床总有效率、治疗情况及不良反应比较。结果实验组总有效率高于对照组(97.06%vs76.47%),两组比较差异有统计学意义(P<0.05);实验组患者控制出血时间及完全止血时间均少于对照组,两组比较差异有统计学意义(P<0.05);两组患者未发生严重不良反应。结论雌孕激素序贯疗法在青春期功血治疗中具有较好的临床效果,能够提高治疗的总有效率,有效的控制出血和完全止血,且不良反应少。

Objective To investigate the value of estrogen and progestin sequential therapy in the treatment of adolescent dysfunctional uterine bleeding. Methods 68 patients were randomly divided into two groups, the control group and the experimental group （n = 34 cases）. The experimental group was treated with estrogen and progestin （medroxyprogesterone acetate estradiol valerate） treatment, and the control group was treated with estrogen （valerate estradiol） treatment. The total clinical efficiency, treatment and adverse reactions after 20 days＇ treatment for stopping bleeding were compared. Results The total efficiency rate of the experiment group was higher than that in the control group （97.06% vs 76.47%）, the difference was statistically significant （P 〈0.05）. The control bleeding time and stop bleeding time in the experimental group were less than the control group. Compared between the two groups, the difference was statistically significant （P 〈0.05）. There were not serious adverse reactions in the two groups. Conclusion The clinical effect for estrogen and progesterone sequential therapy in the treatment of adolescent dysfunctional uterine bleeding is better. It can improve the treatment efficiency, effective control of bleeding and complete hemostasis, and with less adverse reactions.