摘要
目的:分析14例毛囊黏蛋白病患者的临床和组织病理表现。方法:对14例毛囊黏蛋白病患者临床资料进行回顾性分析,包括临床、组织病理、误诊及治疗情况。结果:该病多见于中青年男性,皮损好发于头部;14例患者均有毛囊周围细胞浸润和黏蛋白沉积(占100%);对羟氯喹的治疗效果均不好;14例中误诊为8例(占57%)。12例患者为慢性良性型,2例属于恶性型。结论:该病皮损主要分布头部,基本皮疹为浸润的斑块和结节。皮损组织病理检查显示毛囊及其周围有黏蛋白聚积,阿新蓝染色阳性提示诊断毛囊黏蛋白病的线索。
Objective: To analyze the clinical and histopathological features of follicular mucinosis. Methods: The clinical and histopathological data of 14 cases of follicular mueinosis diagnosed and treated in our hospital was retrospectively ana- lyzed. Results: They were all male patients, with the age from eleven year-old to seventy year-old (thirty-four year-old in average). The skin lesions were mainly distributed on the head, presented as nodules, or plaques. Histopathological examination revealed perifollicular deposition of mucin and (lymphocyte cell) infiltration in all the 14 cases (100%), with positive Aleianblue staining. Misdiagnosis occurred in 8 cases (accounting for 57%), which were corrected according to (histopathological examination). Among them, 12 cases were confirmed as chronic benign type and the other two cases diagnosed as malignant type. The response to hydroxychloroquine was not satisfactory. Conclusions: The patients in this group are mainly young and middle-aged males with the lesions on the head. Most cases belong to the chronic benign type. Histopathology reveals peri- follicular mucin deposition with positive Alcian-blue staining, which suggests the diagnostic clue of follicular mucinosis.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2013年第1期3-6,共4页
Journal of Clinical Dermatology