肝癌组织雌激素受体表达与生物学特征的研究

A study of estrogen receptor expressing and biologic feature in hepatocellular carcinoma

目的：探讨雌激素受体（ｅｓｔｒｏｇｅｎ ｒｅｃｅｐｔｏｒ， ＥＲ）在肝细胞肝癌（ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａ， ＨＣＣ）中的表达及其与ＨＣＣ生物学特征的关系。方法：用免疫组织化学方法检测了４３例ＨＣＣ及对应癌旁肝组织及４例正常肝组织的雌激素受体的表达，经大体及显微镜检查了这些肝细胞肝癌的病理特征。结果：雌激素受体阳性率在肝细胞肝癌为 ３７．２１％，癌旁肝组织为６０．４６％，正常肝组织 １００％；雌激素受体阳性肝癌６２．５％为单结节，５６． ２５％有完整包膜，８１．２５％无血管侵犯，其构成比高于雌激素阴性肝癌的 ２５.９２％、２２．２２％和 ４８．１５％，统计学差异有显著性；小肝癌的雌激素受体阳性率为６６.６７％显著高于大肝癌的２５．８１% （Ｐ＜０．０５）。结论：肝细胞肝癌可能具有一定的激素依赖性，且雌激素受体阳性肝癌与雌激素阴性肝癌相比，前者的生物学行为和预后较好。

Objective: To investigate the clinico-pathologic significance of estrogen receptor (ER) in hepatocellular carcinoma(HCC). Methods: The ER expression was examined by immunohistochemical assay using specific ER monocolon antibody in 43 cases of HCC and their paracarcinoma liver tissues, and 4 cases of normal liver as control. Some pathologic characteristics were observed with gross and microscopic examination. Results: The ER was expressed in HCC, parama liver and normal liver tissues. The positive rate of ER were 37.21%,60. 46% and 100% in HCC, paracarcinoma liver and normal liver tissues, respectively. ER positive HCC had higher incidence of single nodule, complete encapsulation and lower invade vessels as compared to ER negative HCC (P<0.05). In small liver cancer ER positive rate was 66.67% which was higher than in larger liver cancer 25.81% (P <0.05). Conclusion: HCC may be an androgen dependent tumor. The results suggest that ER positive HCC has less malignant biologic behavior and better prognosis than ER negative HCC.