胃癌组织中微血管数量与肝转移的关系

The relationship between microvessel count, distribution pattern in gastric cancer tissue and liver metastasis

目的：本试验拟通过对胃癌组织中微血管的数量、血管分布方式的检测，探讨其与肝转移的关系。方法：收集胃癌石蜡标本７５例，其中肝转移２９例，采用兔抗入第Ⅷ因子相关抗体，ＳＡＢＣ免疫组化方法，在２００倍镜下计数每个病例癌组织中的血管数，以均值作为区分高。低血管组的标准。按血管在癌组织中的分布方式分为：肿瘤内型和间质型。检测胃癌组织中的微血管数量和分布方式，比较与肝转移的关系。结果：全组病例的微血管数范围为 ５－７６（个），平均数±标准差为 １６． ７１±１０.７２；有肝转移和淋巴结转移的病例与胃癌组织中微血管的数量呈正相关（Ｐ＜０.０５）；微血管分布方式，肿瘤内型者有较高的肝转移发生率（Ｐ＜０.０５）。结论：１、胃癌组织中微血管计数与肝转移、淋巴结转移呈正相关，即随着微血管量的增加，肝转移、淋巴结转移的可能性明显增加。２、肿瘤内型血管分布者肝转移发生率显著增高。３、高微血管组比低微血管组病例的预后明显为差。

Objective: This experiment aimed to find the relationship between microvessel count as well as its distribution type (intratumor and peritumor) in the tissue of gastric cancer and hepatic metastasis. Methods: There were 75 gastric cancer cases, in which 29 with liver metastasis, included in this study. SABC immunohistochemical method was used to examine the number and the distribution type of microvessel in gastric cancer tissue. Results: The average microvessel count (MVC) in the tumor slices of this group was 16. 71±10. 72 ranging from 5-76. MVC in gastric cancer tissue significantly correlated with hepatic metastasis and lymph node metastasis(P < 0. 05 ); tumors with microvessel of intratumor type and MVC≥16 had higher hepatic metastasis rate (P < 0. 05) although they were treated with eurative operation. Conclusions: 1. The microvessel collnt in the tissue of gastric cancer significantly correlated with hepatic metastasis and lymph node metastasis; 2. The distrihution pattern of microvessel have close relationship with hepatic metastasis; 3. The survival rate of high MVC group is lower than that of low MVC group, though they were all treated with curative operation.