谷氨酸和一氧化氮在新生儿缺氧缺血性脑病发病中的作用

Role of Glutamate and Nitric Oxide in Newborn Infants with Hypoxic Ischemic Encephalopathy

目的 研究新生儿缺氧缺血性脑病 (HIE)患儿脑脊液谷氨酸和一氧化氮 (NO)水平变化 ,探讨二者在新生儿 HIE中的作用及相互关系。 方法 对 2 4例新生儿 HIE脑脊液谷氨酸和 NO水平进行检测 ,并与 8例对照组比较。 结果 重度 HIE组脑脊液谷氨酸和 NO水平明显高于对照组[(分别为 92± 42和 148.7± 5 .4,高于 45± 5和 83.3± 2 7.5 )μmol/ L ],谷氨酸和 NO水平呈显著正相关(r=0 .6 2 ,P<0 .0 1)。 结论 谷氨酸和 NO在新生儿 HIE的发生和发展过程中具有重要意义。

Objective To study the change of cerebro spinal fluid(CSF) glutamate and nitric oxide (NO) levels in neonatal hypoxic ischemic encephalopathy(HIE), and explore the role of glutamate and NO in the pathogenesis of neonatal HIE and relationship between each other. Methods CSF glutamate and NO levels were studied in 24 newborn infants with HIE, and 8 neonates served as control. Results CSF glutamate and NO levels were much higher in newborn infants with the moderate and severe HIE when compared with the control group and mild HIE; glutamate levels were significantly related to NO levels. Conclusion Glutamate and NO are significant to the pathogenesis of neonatal HIE.