μ阿片受体在大鼠腹主动脉、心脏和肾脏的分布和定位

Distribution and localization of μ opioid receptor in the abdominal aorta,heart and kidney of rats

目的观察μ阿片受体(MOR)在正常大鼠腹主动脉、心脏和肾脏组织中的分布和定位。方法选用成年SD大鼠腹主动脉、心脏和肾脏冰冻切片进行免疫组织化学染色,对MOR在大鼠心脏、大动脉和肾脏的分布进行定位分析。结果MOR免疫阳性物质主要分布于腹主动脉内皮层和肾小球毛细血管内皮,而在心脏未发现。结论 MOR在大鼠腹主动脉内皮和肾小球毛细血管内皮有分布。

Objective To investigate the distribution of μ opioid receptor （MOR） in the abdominal aorta, heart and kidney of normal Sprague - Dawley rats. Methods Immunohistochemistry （IHC） technique was used to detect the μ opioid receptor in the frozen sections of the heart, abdominal aorta and kidney tissues of normal Sprague - Dawley rats. Results μ opioid receptors were detected in the endothelial cells of abdominal aorta, the capillaries of the glomerulus, but not in the endocardium. Conclusion μ opioid receptors exist in the abdominal aorta and kidney of rats.