急性肺动脉栓塞患者CT阻塞指数与缺氧严重程度的相关性研究

Correlation between obstruction index with CT pulmonary angiography and severity of hypoxia in acute pulmonary embolism

目的:评价急性肺动脉栓塞患者CT阻塞指数(CTOI)与缺氧严重程度的相关性。方法:对24例急性肺动脉栓塞患者(栓塞组)的CT肺动脉造影(CTPA)资料进行回顾性分析,了解肺动脉CTOI与血氧饱和度(SO2)的相关性;以30例无栓塞的患者作为对照组,了解栓塞患者及无栓塞患者的SO2是否有差异;以SO2值94%为标准,将肺动脉栓塞患者分为缺氧组(<94%)和非缺氧组(≥94%),了解引起缺氧的肺动脉栓塞程度。结果:肺动脉栓塞组和对照组的SO2分别为:(89.96±7.68)%和(97.53±5.26)%,肺动脉栓塞组的SO2明显低于对照组(P<0.05);CTOI与SO2之间呈明显负相关(r=0.45,P=0.03),随着CTOI的增加,SO2降低越明显;肺动脉栓塞患者中,非缺氧组CTOI值的95%可信区间为0%～49.20%,缺氧组CTOI值的95%可信区间为39.88%～100%,CTOI值为40%～50%时,患者处于氧供不足的临界状态。结论:急性肺动脉栓塞患者CTOI与缺氧严重程度具有相关性,SO2值低于94%时,提示肺动脉栓塞超过约50%。

Objective： To evaluate the correlation between CT obstruction index（CTOI）and severity of hypoxia in acute pulmo-nary embolism. Methods： The CT pulmonary angiography（CTPA） of 24 patients （embolism group） with acute pulmonary embol-ism were retrospectively analyzed. Analyzed the correlation of CTOI and blood oxygen saturation（SO2）. 30 patients without pul- monary embolism served as control, compared the SO2 between the embolism group and the control group. 24 patients with acute pulmonary embolism were divided into hypoxia（〈94%）and non-hypoxic group（≥ 94%）, estimated the extent of pulmonary embolism to which could lead to hypoxia. Results： In the embolism group and the control group, the SO2 were 89.96 % 4-7.68% and 97.53%±5.26% respectively. The values of SO2 in the embolism group were significant lower than that in the control group（ P 〈0.05）. There was a negative correlation between CTOI and SO2 （ r=0.45, P=0.03） ,SO2 reduced accompany with the increase of CTOI. The 95% confidence interval of CTOI was 0%-49.20% in non-hypoxic group,and 39.88%-100% in the hypoxic group. Patients were in the critical state when the CTOI value ranged from 40% to 50%. Conclusion：There is a cor-relation between CTOI and hypoxia in the patients with acute pulmonary embolism. It＇s suggested that more than 50% of pul-monary is embolized when the SO, is lower than 94%.