显微支撑喉镜下CO_2激光手术或联合干扰素治疗复发性小儿喉乳头状瘤疗效对比

Effect of CO_2 laser surgery combined with interferon on recurrent juvenile laryngeal papillomatosis

目的探讨白细胞干扰素联合显微支撑喉镜下CO2激光手术治疗复发性小儿喉乳头状瘤的临床疗效。方法回顾性分析61例复发性小儿喉乳头状瘤的临床治疗资料,运用解剖划分法,评估单纯显微支撑喉镜下CO2激光治疗(A组)、或联合干扰素共同治疗(B组)复发性小儿喉乳头状瘤这两种方案的临床效果。结果两组乳头状瘤范围,①术前均为1～8个解剖亚区,平均值A组为(3.45±1.86)个、B组为(3.53±1.67)个解剖亚区;②术后A组1～4个、平均(2.09±0.87)个解剖亚区,B组1～3个、平均(1.47±0.63)个解剖亚区(P<0.05)。结论单纯显微支撑喉镜下CO2激光手术与联合干扰素治疗复发性小儿喉乳头状瘤均能延缓肿瘤复发,联合治疗组较单纯手术组复发范围小。

Objective To evaluate the clinical effect of CO2 laser microsurgery through suspension laryngoscope combined with human leukocyte interferon on children with recurrent laryngeal papilloma. Methods Clinical data of 61 recurrent laryngeal papilloma patients, treated in E. N.T. Department of Qilu Hospital from 2004 to 2009, were reviewed. All the patients underwent CO2 laser microsurgery through suspension laryngoscope. According to the post- operative medication, the patients were further divided into group A （ no interferon） or group B （ with interferon）. The number of anatomical sites involved by papilloma were counted before and after the treatment. Results Before the operation, the number of anatomical sites involved by papilloma before operationin both groups were 1 to 8 with the average of 3.45 ± 1.86 in group A and 3.53 ±1.67 in group B. After the treatment, the number of sites turned into 1 to 4 in group A and 1 to 3 in group B with the average value of 2.09 ± 0.87 and 3.53 ± 1.67, respectively （ P 〈 0.05 ）. Conclusion CO2 laser microsurgery, with or without interferon treatment, can delay the recurrence of laryngeal papilloma. However, The number of sites involved by papilloma decreases significantly in the microsurgery combined with interferon treatment.