不同饮酒量对缺血性脑卒中患者执行功能的影响

Effect of different quantity of alcohol drinking on the executive function of patients with ischemic stroke

目的探讨不同饮酒量对脑卒中患者执行功能的影响。方法选取河北联合大学附属医院神经内科缺血性脑梗死病人467例,将其按成饮酒量的不同分成不饮酒组、轻度饮酒组、中度饮酒组和重度饮酒组,应用威斯康星卡片测验系统(WCST)对稳定期(住院15d后)四组患者进行执行功能评测。结果缺血性脑梗死患者不饮酒组WCST的六项评分与轻度饮酒组相比无显著差异(P>0.05);不饮酒组的WCST的持续应答数、错误应答数、持续性错误数、非持续性错误数明显低于中度、重度饮酒组(P<0.05),正确应答数高于重度饮酒组(P<0.05)。重度饮酒组WCST的持续应答数、错误应答数、持续性错误数、非持续性错误数明显高于轻度、中度饮酒组(P<0.05),而正确应答数低于轻度、中度饮酒组(P<0.05)。结论重度饮酒可使缺血性脑梗死患者执行功能下降,应给予干预。

Objective To discuss the effect of different quantity of alcohol drinking on the executive function of patients with ische- mic stroke. Methods WCST was conducted in 467 patients with isehemie stroke on 15 days after hospitalization and grouped to non-, mild-, moderate drinkers and heavy drinker. Results There were no significant difference in the scores of six index both non-drinkers and mild drinkers （ P 〉 0.05 ）. WCST with non-drinkers showed that the scores of perseverative response, response errors, perseverative response er- rors, non-perseverative response errors were lower than those of moderate drinkers and heavy drinkers （ P 〈 0.05 ） ; and the scores of response correct was higher than that of heavy drinkers （ P 〈 0. 05 ）. WCST with heavy drinker showed that the scores of perseverative response, response errors, perseverative response errors, non-perseverative response errors were higher than those of mild drinkers and moderate drinkers （ P 〈 0.05 ）. The scores of response correct was lower than that of moderate and heavy drinkers （ P 〈 0. 05 ）. Conclusions Heavy drinking make the executive function with ischemic stroke patients decline, intervention should be given to patients with ischemie stroke.