1％聚桂醇在面部血管瘤及血管畸形治疗中的应用

Application of 1% lauromacrogol in the treatment of facial refractory hemangioma and vascular malformations

目的探讨1％聚桂醇注射液治疗面部血管瘤及血管畸形的临床疗效。方法2009年9月至2011年11月，临床治疗55例不同类型的颜面部难治性血管瘤及血管畸形患者，男20例，女35例，年龄为1个月至30岁，瘤体面积为1．0am×（0．5—5．0）cm×10．0cm，采用1％聚桂醇瘤内注射治疗，根据患者的年龄、瘤体大小和深度决定用药浓度、剂量和注射次数，个体1次最大剂量不超过10ml，两次注射间隔为1—4周。结果经3—16个月随访，治愈41例，基本治愈9例，有效5例。2例出现局部皮肤破溃，换药后创面愈合。结论1％聚桂醇作为一种硬化剂治疗颜面部难治性血管性疾病，安全有效，且简单易行。

Objective To investigate the clinical effect of 1% lauromacrogol for the treatment of facial refractory hemangioma and vascular malformation. Methods From Sept 2009 to Nov 2011, 55 patients （20 male, 35 female, 1 month to 30 years） with different types of facial hemangioma and vascular malformation about 1.0 cm ·（0. 5-5.0） cm · 10.0 cm in size, underwent 1% lauromacrogol intratumor injection therapy. Generally, the injection dose, concentration, frequency were determined by the age of the patients, the volume and depth of the lesion. The dose was limited to 10 mg every time. The injection interval is 1--4 weeks. Results After followed up for 3-16 months, 41 cases were cured, 9 cases were greatly improved, and 5 were partially improved. Skin necrosis happened in only 2 cases. Conclusions Lauromacrogol is safe, simple and effective as a sderosing agent for the treatment of facial refractory hemangioma and vascular malformation. It provides a new and alternative way for the treatment of facial refractory hemangioma and vascular malformation.