线粒体复合体功能抑制对神经元离子通道和神经递质释放的影响(英文)

The influence of mitochondrial complex inhibition on neuronal ion channel and neurotransmitter release

线粒体复合体功能抑制在很多神经系统退行性疾病中都有报道,因此线粒体复合体功能抑制对神经元功能的影响和机制备受关注。神经元功能的完成离不开动作电位的产生和动作电位诱发的神经递质释放。神经元动作电位的产生主要是由电压依赖的钠离子通道和电压依赖的钾离子通道共同介导的。而电压依赖的钙通道直接参与了神经递质释放。某些病理原因导致的这些离子通道的功能异常会直接影响神经元功能,甚至导致神经元死亡。因此研究线粒体复合体抑制对神经元离子通道和神经递质释放的影响和机制对于了解相关神经系统疾病发病机制非常重要。本文对以上方面的研究进展做一综述。

Mitochondrial complex inhibition has been described in the pathophysiology of many neurodegenerative diseases, and the functional changes of neuron induced by mitochondrial complex inhibition and the mechanism are concerned. Neuronal function depends on action potentials and neurotransmitter release. Voltage dependent sodium/potassium ion channels mediate generation of neuron action potentials. And voltage dependent calcium ion channels are directly involved in the process of neurotransmitter release. The functional changes of those ion channels under some pathological conditions can induce neuron dysfunction, even death. Therefore, understanding the influence of mitochondrial complex inhibition on neuronal ion channels and neurotransmitter release is helpful to illuminate the pathophysiology of neurodegenerative diseases. This review will highlight recent progress in this field.