脉冲振荡法测定慢性阻塞性肺病通气阻力

Measuring of airway resistance by impulse oscillometry in patients with chronic obstructive pulmonary diseases

目的 :探讨脉冲振荡法 (ImpulseOscillometrysystem ,IOS)对慢性阻塞性肺病 (COPD)患者肺功能的临床判断价值。方法 :使用德国Jaeger公司生产的MasterscreenPFT型肺功能仪测定 114例COPD病人和作为对照的健康成人的通气阻力。结果 :Fres、zrs、R5、R2 0、Zrs %、R5 %、R2 0 %、X5、Rc、Rp各组间差异有非常显著性意义 (P <0 .0 1)。R2 0、R2 0 %对照组和肺气肿组有显著性差异 (P <0 .0 5 ) ,对照组和肺心病组有非常显著性差异 (P <0 .0 1)。Zrs、R5、Zrs%、R5 %、X5慢层和肺心病组有显著性差异 (P<0 .0 5 )。Fres、Zrs、R5、Zrs%、R5 %、X5、Rp肺气肿组和肺心病组间有非常显著性差异 (P <0 .0 1)。结论 :IOS无需病人努力配合 ,尤其适用于以往不能耐受肺功能检查的COPD重病人及一些高龄患者 ,IOS能很好反映COPD病人的气道阻力和肺顺应性的变化 。

Objective:To estimate the value of using impulse oscillometry(IOS) to measure airway resistance in patients with chronic obstructive pulmonary diseases(COPD).Methods:By using IOS method,12 parameters of airway resistance were measured in 114 COPD patients and were compared with those of 44 healthy controls.Results:Fres,zrs,R5,R20,Zrs%,R5%,R20%,X5,Rc and Rp were valuable in the diagnosis of airway resistance (all P<0.01 between comparing groups).Conclusion:IOS is less dependent on the cooperation of patients,it is particularly useful for elders and emergent patients.IOS can reflect the changes of airway resistance and compliance.