食管癌组织STAT3和p38表达及其临床意义的研究

Expressions and clinical significance of STAT3 and p38 in esophageal carcinoma tissues

目的:探讨食管癌组织中STAT3和p38的表达,及其在食管癌发生发展和预后中的临床意义。方法:采用免疫组化SP法检测STAT3和p38在89例食管癌组织及20例癌旁组织中的表达,并分析其与食管癌临床病理特征的联系。结果:STAT3和p38在食管癌组织中阳性率明显高于癌旁组织,P<0.05。STAT3和p38表达水平与患者的年龄、性别、组织类型及位置无关(P>0.05),而和组织分化程度呈负相关(r值分别为-0.395和-0.389,P值均<0.05),与淋巴结转移呈正相关,r值分别为0.242和0.249,P值均<0.05。两者在癌组织中的表达存在正相关关系,r=0.329,P=0.002。结论:STAT3和p38在食管癌的发生发展中起重要作用,并有助于判断恶性程度及预后。

OBJECTIVE： To investigate STAT3 and p38 protein expressions in human esophageal carcinoma tissues, and analyze the clinical significance in development and prognosis of esophageal carcinoma. METHODS： Immunohisto- chemical was used to determine the expression of STAT3 and p38 protein in 89 cases of esophageal carcinoma tissues and 20 cases of corresponding normal tissues. RESULTS： The expression of STAT3 and p38 protein in esophageal carcinoma cell were significantly higher than those in normal esophageal epithelium（P〈0.05）. The expression of the 2 proteins were positively correlated with lymph node metastasis（r values were 0. 242 and 0. 249 respectively）,and negatively correlated with degree of differentiation（r values were -0. 395 and -0. 389 respectively）,but not with years,gender,types and site （P〉0.05）. CONCLUSION： The trial suggestes that stat3 and p38 play a critical role in the carcinogenesis of the esopha- gus and contribute to judge the malignancy degree and prognosis.