摘要
目的:探讨食管鳞癌组织AIB1的表达水平及其与Ki-67的相关性。方法:用免疫组织化学SP方法,联合检测20例正常食管鳞状上皮组织和60例食管鳞癌组织中AIB1和Ki-67的表达,分析AIB1的表达与临床病理参数的关系以及与Ki-67的相关性。结果:20例正常食管鳞状上皮组织中呈微弱表达或不表达,60例食管鳞癌组织中有25例(41.6%)为AIB1高表达,P<0.05。AIB1的表达水平与临床分期、淋巴结转移有明显相关性;在T3~T4期的表达水平高于T1~T2期(P<0.05),在有淋巴结转移的组织中表达较高(P<0.05),而其在不同性别、年龄、病理学分型中的表达差异无统计学意义,P>0.05;Ki-67蛋白在食管鳞状细胞癌中的表达为65.0%(39/60),在39例Ki-67蛋白阳性表达的食管鳞癌组织中有29例同时表达AIB1,且其中25例AIB1过表达,AIB1与Ki-67的表达呈中度正相关,P<0.01。结论:AIB1蛋白与食管鳞癌的临床分期和淋巴结转移有相关性,Ki-67可能也是AIB1蛋白非类固醇激素受体途径的相关蛋白之一。
OBJECTIVE:To investigate the expression of AIB1 in human esophageal squamous cell carcinoma and its correlation with expression of Ki-67. METHODS: The immunohistochemical method SP was used to analyze the expression and clinical significance of AIB1 and Ki-67 in 60 cases of esophageal squamous cell carcinoma,20 cases of control group (the normal esophageal organization),and analyze the correlation between as well as the two relations. RESULTS: In 20 cases of normal esophageal mucosa cells the high expression of AIB1 were the normal level (located in the nucleus, faint expression or not expressed) , but in esophageal squamous cell carcinoma the high expression of AIB1 were 41.6% (P〈 0.05). Moreover,overexpression of AIB1 was observed more frequently in esophageal squamous cell carcinoma with late T stages (T3/T~) and lymph node metastases, P^0.05. There was not significant difference in the positive expression of AIB1 among gender,age and pathological type (P^0.05) ;Ki-67 was expressed in 65.0%(39/60) of patients with esoph- ageal squamous cell carcinoma, P^0. 05. Ki-67 was expressed in 39 cases in the esophageal squamous cell carcinoma group,among which AIB1 was expressed in 29 cases. The expression of AIB1 was positively correlated with that of Ki-67 (P〈0.01). CONCLUSIONS: AIB1 protein expression was associated with the T stage and lymph node metastase. Ki-67 may play a role in AIB1 through nonsteroid receptor pathway.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第18期1389-1392,共4页
Chinese Journal of Cancer Prevention and Treatment