摘要
目的:探讨食管鳞癌组织AIB1的表达水平及其与Ki-67的相关性。方法:用免疫组织化学SP方法,联合检测20例正常食管鳞状上皮组织和60例食管鳞癌组织中AIB1和Ki-67的表达,分析AIB1的表达与临床病理参数的关系以及与Ki-67的相关性。结果:20例正常食管鳞状上皮组织中呈微弱表达或不表达,60例食管鳞癌组织中有25例(41.6%)为AIB1高表达,P<0.05。AIB1的表达水平与临床分期、淋巴结转移有明显相关性;在T3～T4期的表达水平高于T1～T2期(P<0.05),在有淋巴结转移的组织中表达较高(P<0.05),而其在不同性别、年龄、病理学分型中的表达差异无统计学意义,P>0.05;Ki-67蛋白在食管鳞状细胞癌中的表达为65.0%(39/60),在39例Ki-67蛋白阳性表达的食管鳞癌组织中有29例同时表达AIB1,且其中25例AIB1过表达,AIB1与Ki-67的表达呈中度正相关,P<0.01。结论:AIB1蛋白与食管鳞癌的临床分期和淋巴结转移有相关性,Ki-67可能也是AIB1蛋白非类固醇激素受体途径的相关蛋白之一。
OBJECTIVE：To investigate the expression of AIB1 in human esophageal squamous cell carcinoma and its correlation with expression of Ki-67. METHODS： The immunohistochemical method SP was used to analyze the expression and clinical significance of AIB1 and Ki-67 in 60 cases of esophageal squamous cell carcinoma,20 cases of control group （the normal esophageal organization）,and analyze the correlation between as well as the two relations. RESULTS： In 20 cases of normal esophageal mucosa cells the high expression of AIB1 were the normal level （located in the nucleus, faint expression or not expressed） , but in esophageal squamous cell carcinoma the high expression of AIB1 were 41.6% （P〈 0.05）. Moreover,overexpression of AIB1 was observed more frequently in esophageal squamous cell carcinoma with late T stages （T3/T~） and lymph node metastases, P^0.05. There was not significant difference in the positive expression of AIB1 among gender,age and pathological type （P^0.05） ;Ki-67 was expressed in 65.0%（39/60） of patients with esoph- ageal squamous cell carcinoma, P^0. 05. Ki-67 was expressed in 39 cases in the esophageal squamous cell carcinoma group,among which AIB1 was expressed in 29 cases. The expression of AIB1 was positively correlated with that of Ki-67 （P〈0.01）. CONCLUSIONS： AIB1 protein expression was associated with the T stage and lymph node metastase. Ki-67 may play a role in AIB1 through nonsteroid receptor pathway.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第18期1389-1392,共4页
Chinese Journal of Cancer Prevention and Treatment
