急性脑梗死患者血清抵抗素水平与胰岛素抵抗的关系

Relationship Between Serum Resistin Level and Insulin Resistance in the Patients with Acute Cerebral Infarction

目的探讨急性脑梗死患者血清抵抗素水平与胰岛素抵抗的关系。方法选择68例急性脑梗死患者和40例健康体检者(对照组),采用ELISA检测血清抵抗素、空腹胰岛素等指标,并分析血清抵抗素水平与胰岛素抵抗指数及其他检测指标的相关性。结果与对照组比较,急性脑梗死组血清抵抗素水平、胰岛素水平、胰岛素抵抗指数明显升高(P<0.01),胰岛素敏感性指数、高密度脂蛋白胆固醇水平明显低于对照组(P<0.05);急性脑梗死组抵抗素水平与体质指数、空腹胰岛素、胰岛素抵抗指数呈正相关,与高密度脂蛋白胆固醇、胰岛素敏感性指数呈负相关(P<0.05)。对脑梗死的危险因素行多因素Logistic回归分析显示,抵抗素、胰岛素抵抗指数、胰岛素敏感性指数、血压控制情况和年龄进入回归方程(OR分别为3.505、2.222、-0.589、5.367及2.481)。结论脑梗死患者可能存在胰岛素抵抗,血清抵抗素水平可能与胰岛素抵抗密切相关。

Aim To investigate the relationship between serum resistin level and insulin resistance （IR） in the patients with acute cerebral infarction （ACI）. Methods Fasting serum resistin and insulin （INS） levels were deter- mined by ELISA in 68 patients with ACI and 40 healthy control subjects, the correlation among resistin, insulin resistance index （IRI） and other subjects were analyzed. Results Compared with the control subjects, there were significantly higher fasting serum resistin, insulin level and IRI （P 〈 0. 01 ） and lower QUICKI, high density lipoprotein cholesterol （HDLC） in the ACI patients （P 〈 0. 05 ）. There was a positive correlation between resistin and body mass index （BMI）, insulin, IRI and negative correlation between resistin and QUICKI, HDLC （ P 〈 0. 05）. Resistin, IRI, QU1C- KI, blood pressure and age were the major risk factors of ACI by Logistic （ OR = 3. 505, 2. 222, - 0. 589, 5. 367 and 2. 481 ）. Conclusions IR may exist in the patients with ACI and serum resistin level may be associated with IR.