结直肠癌^(18)F-FDG的摄取与HK-Ⅱ表达的相关性

Relationship between ^(18)F-fluorodeoxyglucose uptake and expression of HK-Ⅱ in colorectal cancer

目的探讨结直肠癌的18F标记的脱氧葡萄糖(18F-FDG)摄取与肿瘤组织己糖激酶-Ⅱ(HK-Ⅱ)表达的相关性。方法 20例结直肠癌患者术前进行18 F-FDG正电子发射断层显像(PET)-CT检查,测定肿瘤平均标准摄取值(SUVmean)。应用免疫组织化学法检测肿瘤组织HK-Ⅱ的表达;分析SUVmean与组织病理关系及与HK-Ⅱ表达的相关性。结果 20例结直肠癌患者均为高摄取,SUVmean为5.42±1.67。浸润型SUVmean为6.55±1.63,明显高于肿块型的4.20±1.29和溃疡型的5.83±1.60(P<0.05)。有远处转移组SUVmean为7.14±1.07,高于无转移组的4.84±1.41(P<0.05)。SUVmean与HK-Ⅱ的表达呈正相关(r=0.589,P<0.01)。结论结直肠癌组织的18F-FDG摄取与HK-Ⅱ表达呈现正相关。

Objective To study the relationships between 18 F-fluorodeoxyglucose （18 F-FDG） uptake and expression of hexokinase-Ⅱ （HK-Ⅱ ） in colorectal cancer in patients with colorectal cancer. Methods 18 F-FDG positron emission tomography（PET-CT） examination was performed in 20 patients with colorectal cancer. The mean standard uptake value （SUVmean） was measured. The expression of HK-Ⅱ was detected semiquantitatively by immunohistochemistry. The correlation of histopathology and HK-Ⅱ with SUVmean was analyzed. Results The 18 F-FDG was highly uptaken by colorectal cancer with a SUVmean value of 5.42±1.67. The SUVmean values of colorectal cancer with infiltrating type, tumor type and ulcer type were 6.55 ± 1.63, 4. 20± 1.29 and 5.83 ± 1.60, respectively（P〈0. 05）. The SUVmean value was higher in colorectal cancer with metastasis than that without （7.14 ± 1.07 vs 4. 84± 1.41） （P〈0. 05）. There was a significant correlation between HK-Ⅱ expression and SUVmean value（r=0. 589,P〈0. 01） in colorectal cancer. Conclusion Expression of HK-Ⅱ is positively correlated with 18 F-FDG uptake in patients with colorectal cancer.