通心络与丹参治疗脑梗死疗效的Meta分析

A Meta-analysis on outcomes of treating cerebral infarction with Tongxinluo and Danshen

目的比较通心络胶囊与丹参治疗脑梗死的临床疗效。方法检索中国期刊全文数据库(CNKI)、万方数据库及维普数据库,收集通心络胶囊治疗脑血管病的随机对照试验(RCT)文献,对照组采用丹参治疗者,用RevMan 5.0软件进行统计分析。结果共纳入合格文献9篇,患者716例。在改善临床疗效、降低血清总胆固醇(TC)及提高高密度脂蛋白(HDL-C)方面,通心络组优于丹参组(P<0.01)。结论通心络胶囊可以提高脑血管病患者的临床疗效,降低TC,提高HDL-C。

Objective To compare the efficacy of Tongxinluo and Danshen in the treatment of cerebrovascular diseases. Methods Data of treating cerebrovascular diseases with Tongxinluo and Danshen in Chinese literatures were collected by searching for Chinese academic journal （CNKI）, Wanfang database and Weipu database. The analysis was performed according to Cochrane Handbook 5. 0 quality evaluation criteria using Rev Man 5.0 software for statistical analysis. Results A total of 9 qualified literatures including 716 cases was put into analysis. The results showed that in terms of improving clinical efficacy, reducing serum total cholesterol（TC） and elevating high-density lipoprotein cholesterol（HDL-C）, Tongxinluo group was better than Danshen group （ P〈0. 01 ）. Conclusion Tongxinluo capsule can improve the clinical efficacy,reduce TC and raise HDL-C in the patients with cerebrovascular diseases.