滋心阴胶囊对麻醉大鼠血流动力学的影响

Effect of Zixinyin Capsules on Hemodynamics of Anesthetized Rats

目的 :研究滋心阴胶囊 ,对麻醉大鼠血流动力学的影响。方法 :测定十二指肠注射滋心阴胶囊剂影响麻醉大鼠动脉收缩压 (SAP)、舒张压 (DAP)、左室内收缩峰值压 (LVSP)。结果 :其下降程度为LVSP >DAP >SAP。在心率不变的同时伴有 +dp/dtmax、Vmax的降低 ,这表明滋心阴胶囊剂可能通过负性肌力作用来降低心肌耗氧量。结论 :滋心阴胶囊能缓解冠心病心绞痛、心肌梗塞时供氧和需氧的失衡。

Objective:To study the effect of zixinyin Capsules on hemodynamics of anesthetized rats.Mothods:The systolic artery pressure (SAP), diastolic artery pressure (DAP), left peak value systolic pressure (LVSP) of anesthetized rats, induced by perfusion of zixinyin Capsules into rat's duodenum, were determined. Results: The decreasing degrees were as follows: LVSP>DAP>SAP. while heart rate was unchanged, +dp/dt max and v max decreased. It was suggested that zixinyin Capsules could decrease the oxygen consumption of myocardium by the negative intofrogic action.Conclusions:Zixinyin Capsules can improve the imbalance of oxygen supply and oxygen requirement when the angine pectoris and myocardiac infarction of patients with coronary heart disease attacking.