基于HF酸蚀＋阳极氧化处理的μm/nm表面对种植体早期骨结合的影响

Effect of Micro/nanorough-surface Implants by Hydrofluoric Acid Etching and Anodizing on Early Osseointegration

目的:评价μm/nm表面对种植体早期骨结合的影响。方法:40枚种植体平均分为2组,对照组为机械加工表面;实验组为μm/nm表面。植入20只大鼠股骨远端,术后即刻、2周行活体显微CT扫描,术后2周处死取材,行组织学染色及生物力学检测。结果:显微CT提示:实验组BV/TV、Tb.Th、Tb.N显著增高,Tb.Sp显著减少。对照组和实验组骨结合率分别为(38.94±9.48)%,(51.49±12.49)%;最大拔出力分别为(64.95±6.11)N,(81.90±13.10)N,2组结果实验组均高于对照组。结论:μm/nm表面可以显著促进种植体早期骨结合。

Objective：To evaluate the effect of micro/nanorough-surface on osseointegration in early stage of dental implants.Methods：Forty implants were equally divided into two groups：machined-surface implants as the control group;micro/nanorough-surface implants as the experimental group.All implants were inserted into the distal femurs of 20 rats randomly.At week 0 and 2 following implantation,microcomputed tomography（micro-CT） scanning in vivo was used to assess micro-architectural changes in the bone around.Two weeks after implantation,all the rats were killed and the femurs with implants were harvested for histomorphometry analysis and biomechanical test.Results：Micro-CT analysis showed that the bone volume ratio,the trabecular thickness and number all increased significantly in the micro/nanorough-group compared with the machined-group,while the trabecular separation decreased significantly in the micro/nanorough-group.The bone-implant-contact were 38.94±9.48% and 51.49±12.49% in the machined-group and the micro/nanorough-group.The maximum pull-out forces were 64.95±6.11N and 81.90±13.10N,respectively.There was significant difference between the two groups in the BIC value and the maximal pull-out forces.Conclusion：Modification with micro/nanorough-surface could promote dental implants osseointegration in early stage of implantation.