长寿与非长寿者子代血脂水平及与apoE基因多态性的关系

Relationship between blood lipid level and apolipoprotein E gene polymorphism in offspring from longevity and non longevity families

目的 探讨遗传基因与血脂谱水平差异的关系。方法 对比分析 7个维吾尔族长寿家系的 86名子孙与 9个维吾尔族非长寿家系的 6 2名子孙的血脂谱水平和apoE等位基因频率分布差异 ,以及apoE基因多态性与血脂谱水平的关系。结果 调整年龄、工作性质后 ,长寿家系子孙不论男女 ,血脂谱中与动脉硬化呈正相关的指标均低于非长寿家系子孙 ,而与动脉硬化呈负相关的指标均高于非长寿家系子孙。其中男性甘油三酯 (1 49± 0 14)mmol/L、apoB(0 83± 0 0 4)g/L均显著低于非长寿家系子孙的 (2 11± 0 17)mmol/L和 (1 0 2± 0 0 5 )g/L ,高密度脂蛋白 胆固醇 /低密度脂蛋白 胆固醇 (0 74± 0 0 4)显著高于非长寿家系子孙 (0 5 9± 0 0 5 ) ,女性apoA/apoB(1 74± 0 0 8)显著高于非长寿家系子孙 (1 42± 0 0 9)。长寿家系子孙中等位基因ε4的相对频率 (5 8)显著低于非长寿家系子孙(16 1)。进一步分析发现 ,ε4等位基因携带者血清中总胆固醇、低密度脂蛋白 胆固醇、apoB水平显著高于其他等位基因携带者。结论 长寿家系子孙血脂谱综合指标优于非长寿家系子孙 。

Objective To study relationship between genetic factor and level of blood lipid Methods Levels of blood lipid and difference in apolipoprotein E (apo E) allele frequencies were compared in 86 offspring in seven Uigur longevity families and 62 offspring in nine Uigur non longevity families and their relationship was explored Results After adjustment for age and occupation, blood indicators related to atherosclerosis were all lower in the offspring of longevity families than in non longevity families, and those correlated inversely with it were higher in the former Blood levels of triglyceride and apo B were significant lower ( P< 0 05) and the ratio of HDL ch to LDL ch was significantly higher ( P< 0 05) in male offspring of longevity families than of non longevity families The ratio of apo A to apo B was significantly higher in female offspring of longevity families than of non longevity families Frequency of ε4 allele also was significantly fewer in the offspring of longevity families than of non longevity ones ( P< 0 01) Also, analysis showed that individuals with ε4 allele had higher levels of serum total cholesterol, lower density lipoprotein cholesterol and apo B than those with other alleles Conclusion Average level of blood lipid was better in the offspring of longevity families than that of non longevity families apo E allele polymorphism can in part explain its difference