氨磷汀减轻头颈部恶性肿瘤放疗损伤的临床观察

Clinical treatment of amifostine reduces radiation injury on head and neck cancer

目的探讨氨磷汀联合三维适形放疗对头颈部恶性肿瘤放疗损伤的影响。方法 216例头颈部恶性肿瘤患者随机分为治疗组和对照组。每组108例,行三维适形放疗治疗,总剂量50～72Gy分28～40次5.6～8周完成。治疗组放射治疗前静脉点滴氨磷汀注射剂。结果治疗组有效率为75.0%,对照组有效率为58.3%,两组差异无统计学意义(P>0.05)。治疗组患者的生活质量评分提高率明显高于对照组,两组差异有统计学意义(P<0.05)。治疗组黏膜炎、口干、吞咽困难、血液系统毒性、神经系统毒性发生率均明显低于对照组,两组差异有统计学意义(P<0.05)。结论氨磷汀可减轻头颈部恶性肿瘤放疗损伤,提高患者生存质量,并不影响临床疗效。

Objective To observe the Influence of amifostine combined with three dimensional-conformal radiotherapy（3D-CRT） of head and neck cancer radiation injury effects.Methods 216 cases of patients with head and neck cancer were randomly divided into treatment group and control group.108 patients in the control group were given 3D-CRT,the others in the treatment group were applied amifostine before the application of radiation.Results The elevated rate of Karnofsky score in the two groups was significantly different（P0.05）.The effective rates were 75.0% vs 58.3%（P0.05）.The major toxicity（mucositis、xerostomia、dysphagia、blood system toxicity 、nervous system toxicity）in the treatment group was lower than that in the control group（P0.05）.Conclusions Amifostine can reduce the head and neck cancer radiation injury,and improving patients quality of life without adverse effect on clinical curative effect.