贫血对中晚期子宫内膜癌化疗疗效的影响

Clinical analysis of curative effect in chemotherapy on anemia for advanced endometrial cancer

目的探讨贫血对中晚期子宫内膜癌患者化疗疗效的影响。方法回顾性分析进行药物疗法的164例子宫内膜癌患者的临床资料,其中82例未积极纠正贫血症状的患者设为对照组,另外82例为观察组,采取全程积极纠正贫血,尽量使血红蛋白(Hb)保持在正常水平。对两组患者的临床资料进行对比分析。结果观察组的近期疗效(部分缓解、完全缓解)和远期生存率(1,3,5年)均优于对照组(P<0.05),化疗前患者的Hb水平越低,其化疗后的近期疗效和远期疗效越差。结论对中晚期子宫内膜癌化疗患者,积极纠正化疗前及化疗期间出现的贫血,可增强化疗的近、远期疗效,同时能改善患者的生活质量。

Objective To investigate the degree of anemia in chemotherapy effect for advanced endometrial cancer patients.Methods The clinical date of 164 patients who treatment in our hospital were retrospective analysised the haemoglobin of patients were tested before and after chemotherapy,to understand the relationship between hemoglobin levels and chemotherapy curative effect for endometrial cancer.Results The hemoglobin level of patients before chemotherapy was lower,the short-term and long-term therapeutic effect after chemotherapy was worse;The short term and long term effects of patients who hemoglobin levels was elevated were superior than patients who hemoglobin level was decreased in chemotherapy.Conclusions The hemoglobin levels can affect treatment effect of chemotherapy in endometrial cancer patients,correction anemia before chemotherapy is good for prognosis in endometrial cancer patients.