宫颈癌根治术预后影响因素分析

Analysis of prognostic factors on Radical resection of cervical cancer

目的探讨影响宫颈癌根治术预后的临床病理及生物学因素。方法收集2003年2月至2009年4月间120例行广泛性全子宫切除+双侧盆腔淋巴结切除术患者的临床资料和宫颈癌石蜡标本,随访3年观察其生存情况,同时进行临床病理及生物学因素分析。结果 120例患者的3年存活率为79.2%。单因素分析显示,临床分期、病理分化程度、淋巴结转移、HuR蛋白阳性表达、VEGF蛋白阳性表达、COX-2蛋白阳性表达与预后相关(P<0.05)。多因素分析确定影响宫颈癌手术预后最显著的独立因素为分化程度和血管内皮生长因子(VEGF)蛋白阳性表达(P<0.05)。结论宫颈癌患者采用根治术生存率比较高,而分化程度与VEGF蛋白阳性表达是影响宫颈癌手术预后的最显著独立因素。

Objective To investigate the prognostic factors on Radical resection of cervical cancer for giving reasonable and comprehensive treatment of cervical cancer.Methods Selected 120 cases of paraffin-embedded specimens from February 2003 to April 2009 in our hospital,all cases were received extensive full hysterectomy and bilateral poor cavity lymph node dissection and were followed up for 3-years,then to analyze the clinical pathology and biological factors affecting prognosis.Results The three-year survival rate of this group was 79.2%.Univariate analysis showed that clinical stage,pathological grade,lymph node metastasis,positive expression of HuR,VEGF and COX-2 protein were correlated with prognosis（P0.05）.Multiple factors showed that the pathological grade and VEGF expression were the more risk factors（P0.05）.Conclusions The patients with cervical cancer are more used radical surgery,the survival rate is relatively high,the degree of pathological grade and positive expression of VEGF are the most significant independent factors that impacts cervical cancer surgery prognosis.