RP-HPLC考察注射用更昔洛韦钠在转化糖注射液及转化糖电解质注射液中配伍的稳定性

Stability of ganciclovir for injection mixed with 5% invert sugar injection,multiple electrolytes and invert sugar injection by RP-HPLC

目的考察室温(20±1)℃下,注射用更昔洛韦钠分别与5%转化糖注射液及5%转化糖电解质注射液配伍的稳定性。方法采用反相高效液相色谱法测定配伍液中更昔洛韦0～6 h内的含量变化,并观察配伍液的外观及pH值。结果注射用更昔洛韦与5%转化糖注射液及5%转化糖电解质注射液6 h内配伍液外观、pH及含量均无明显变化。结论在室温(20±1)℃下,注射用更昔洛韦钠分别与5%转化糖注射液及5%转化糖电解质注射液6 h内可配伍使用。

Objective To study the stability of ganciclovir sodium for injection in 5% invert sugar injection,5% multiple electrolytes and invert sugar injection respectively at room temperature [（20±1）℃].Methods The changes of the contents of ganciclovir sodium were determined by RP-HPLC,and the changes of appearance,pH values were observed within 6 hours.Results There were no significant changes in the contents,appearance and pH values of the compatible solution at room temperature [（20±1）℃] for 6h.Conclusions The mixture of ganciclovir sodium for injection and 5% invert sugar injection,5% multiple electrolytes and invert sugar injection can be used respectively after storing for 6h at room temperature [（20±1）℃].