抗结核化疗药物对HBV阳性肺结核患者肝功能的影响分析

Analysis the influences of anti-tuberculosis chemotherapy drugs for HBV positive tuberculosis patients in liver function

目的探讨抗结核药物对乙型肝炎病毒感染的肺结核患者肝功能的影响程度。方法以2009年3月至2011年5月期间在该院治疗肺结核疾病的431例患者为观察对象,根据结核病患者HBVM是否阳性将431例患者分为两组,HBVM(+)组和HBVM(-)组,HBVM(+)组共97例,HBVM(-)组共334例,观察比较两组患者出现肝损伤的例数,ALT值、TBL值、肝损伤出现的时间和肝损伤恢复时间。结果 HBVM(+)组肝损伤的发生率明显高于HBVM(-)组(P<0.05);HBVM(+)组出现肝损伤的时间明显比HBVM(-)组快,而肝损伤的恢复时间也明显较长(P<0.05)。结论 HBV阳性肺结核患者应用抗结核药物后更易发生肝功能损伤,HBV阳性的肺结核患者时应密切监测患者肝功能,预防肝损伤的发生。

Objective To investigate the degree of influence for anti-TB chemotherapy drugs on patients with HBV-positive tuberculosis in liver function.Methods 431 cases with tuberculosis in our hospital were chosen as the research object from March 2009 to May 2011.According to the TB patients HBVM whether positive,431 patients were divided into two groups.HBVM（＋） group and HBVM（-） group,HBVM（＋） group was 97 cases,HBVM（-） group were 334 cases.Compare with cases of liver damage,ALT,TBL,the time of liver damage and liver injury recovery for the two groups.Results The incidence of liver damage of HBVM（＋） group was significantly higher than The incidence of liver damage of HBVM（-） group（P0.05）.The time of liver injury in the HBVM（＋） group was faster than the time of liver injury the HBVM（-） group,the recovery of liver injury time was significantly longer（P0.05）.Conclusion live function of anti-TB chemotherapy drugs on patients with HBV-positive tuberculosisr were damage,HBV positive tuberculosis patients should closely monito liver function of patients,prevent the happening of the liver damage.