早期强化阿托伐他汀治疗对不稳定性心绞痛患者NO、ET-1水平的影响

Effect of early intensive atorvastatin treatment on NO and ET-1 levels in patients with unstable angina

目的:观察强化阿托伐他汀治疗对不稳定性心绞痛(unstable angina,UA)患者早期预后及一氧化氮(nitrogenmonoxidum,NO)、内皮素-1(endothelin-1,ET-1)的影响。方法:收集UA住院患者66例,随机分为普通组(阿托伐他汀20mg/d,35例)、强化组(阿托伐他汀80 mg/d,31例)。比较两组治疗前、治疗后72 h血清NO、ET-1水平及两组1周内的心血管事件发生率。结果:强化组1周内心脏事件发生率明显低于普通组(P<0.01)。与治疗前相比,治疗后72 h两组血清NO水平明显升高(P<0.01),且强化组明显高于普通组(P<0.01);治疗72 h血清两组ET-1与治疗前相比均显著下降(P<0.01),强化组下降幅度大于普通组(P<0.01)。结论:早期强化阿托伐他汀治疗可更有效地升高UA患者的NO水平,降低ET-1水平,减少心脏事件的发生改善早期预后。

Objective： This study aimed to investigate the effects of intensive atorvastatin therapy on the levels of nitrogen monoxidum（NO）,endothelin-1（ET-1） and early prognostic evaluation in hospitalized patients with unstable angina（UA）.Methods： 66 Hospitalized patients with unstable angina were randomly divided into the conventional therapy group（atorvastatin 20 mg/d,n=35） and the intensive treatment group（atorvastatin 80 mg/d,n=31）.All patients were administrated with standard medicine therapy.The serum concentrations of NO and ET-1 were determined at baseline and 72 hours after treatment）.Cardiovascular events were monitored within a week.Results： Compared with the baseline,the levels of NO increased significantly in both of two groups at 72 hours after treatment,especially in intensive treatment group（P0.01）.However,intensive atorvastatin therapy furtherly decreased serum ET-1 concentrations in comparision with conventional therapy（P0.01）.The occurrence of cardiovascular events observed during hospitalization in intensive therapy group is significantly lower than that of conventional treatment group（P0.05）.Conclusion： Early intensive atorvastatin treatment may provide more beneficial effect on reducing cardiovascular events in patients with UA via its multiple mechanisms.