滇池微囊藻毒素对小鼠肾脏的毒性研究

Study the Toxicity of Microcystin in Water of Dianchi Lake on Mice Kidney

为了探索滇池微囊藻毒素对小鼠肾脏的损伤作用,以滇池水华水样提取微囊藻毒素对小鼠进行连续灌胃,然后取其肾组织石蜡包埋、HE染色后对小鼠肾脏组织进行显微结构观察.结果显示,小鼠肾脏形态未见明显异常,但肾小管因细胞脱落而结构不完整,细胞间隙有炎症细胞浸润.表明肾脏可能是微囊藻毒素的靶器官,微囊藻毒素通过破坏肾单位的结构,影响其生理功能.

To study whether Microcystin in Dianchi Lake harms the kidney of mice, mice were intragastrically administered. Microcystin was extracted from Dianchi Lake Water-Blooms samples. Paraffin sections of kidney were stained by HE staining and observed under microscope. It displayed that nephritic modality remained normal ; after intragastrically administered Microcystin, the structure of renal corpuscle was damaged, renal tubule was less integrity because of cell loss, severe inflammatory cells infiltration were found in interstitial area. In conclusion, kidney maybe is target organ of Microcystin which destroy nephron structure and affect its physiology.