早期肠内营养对结肠/直肠癌手术患者肿瘤坏死因子α和白细胞介素6的影响

The Effect of Early Intestines Nutrition on TNF-α and IL-6 in Colorectal Cancer Surgery Patients

目的探讨结直肠癌手术患者术后早期肠内营养对机体肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)的影响。方法将60例结直肠癌手术患者随机分为对照组(30例)、试验组(30例)。实验组于手术后24 h开始进食瑞素肠内营养液,能量计算105 kJ/(kg.d),对照组采用静脉营养。术后72、96、120 h取病例血液,采用酶联免疫吸附试验检测血清TNF-α、IL-6水平,并进行比较。结果试验组术后72、96 h血清炎性介质(TNF、IL-6)水平明显低于对照组,差异有统计学意义(P<0.05)。结论早期肠内营养可减轻结直肠癌手术患者术后炎性反应。

Objective To research the influence early intestines nutrition on TNF-α,IL-6 in colorectal cancer surgery patients.Methods 60 colorectal cancer surgery patients were divided into the control group（n=30）and trial group（n=30）.The trial group started to eat auspicious element nutrition 24 hours after surgery,the energy calculation 105 kJ/（kg·d）,the control group adopted the vein nutrition;72 hours,96 hours,120 hours after surgery blood sample was takenserum TNF-α,IL-6 level was tested by enzyme-linked immunosorbent assay,and comparison was done.Results Blood serum inflammation medium（TNF-α,IL-6）level 72,96 h after surgery was obviously lower than the control group with statistically significant difference（P0.05）.Conclusion Early intestines nutrition may reduce the inflammation response of the colorectal cancer surgery patients.