玻璃酸钠关节腔注射治疗膝关节骨性关节炎64例临床观察

Clinical Observation of Articular Injection of Sodium Hyaluronate in Treatment of Knee Osteoarthritis in 64 Cases

目的探讨玻璃酸钠关节腔注射治疗膝关节骨性关节炎的临床疗效及安全性。方法选取2010年3月至2011年3月期间在西安电力中心医院骨外科治疗的膝关节骨性关节炎患者128例,按随机数字表法分为对照组和治疗组各64例,其中对照组采用曲安缩松关节腔注射,治疗组应用玻璃酸钠关节腔注射,连用5周,比较两组的临床疗效和半年后的复发率。结果治疗组显效率及总有效率均明显高于对照组,而无效率明显低于对照组(P<0.05),半年后随访,治疗组复发率低于对照组,两组比较差异有统计学意义(P<0.05),两组患者治疗期间均未发生明显的不良反应。结论玻璃酸钠关节腔注射治疗膝关节骨性关节炎疗效确切,是治疗膝关节骨性关节炎的有效方法,值得临床推广。

Objective To investigate the clinical efficacy intra-articular injection of sodium hyaluronale in treatment of knee osteoarthriti.Methods Clinical data of 128 patients who underwent knee osteoarthriti in Xi＇an Electric Power Central Hospital during March 2010 and March 2011 were collected,who were randomly divided into control group and treatment group by random number table,64 cases in each.The control group was given triamcinolone articular injection;the treatment group received sodium hyaluronate injection for 5 weeks.The clinical efficacy and half year relapse rate of the two groups were compared.Results After treatment,the excellence rate and the total effective rate of the treatment group was significantly higher than that of the control group（P0.05）,and the inefficiency rate in the treatment group was significantly lower than in control group（P0.05）.All cases got the follow-up survey after 6 monhts,the relapse rate of the treatment group was significantly lower than that of the control group（P0.05）.No significant systemic adverse reactions were observed in both groups.Conclusion The intra-articular injection of sodium hyaluronate in knee osteoarthritis treatment is effective,worthy of promotion in clinic.