血清CEA水平与乳腺癌的转移

Analysis of correlation between serum CEA level and metastases of breast cancer

目的:研究乳腺癌血清CEA与癌灶转移的关系,并比较其在不同器官转移中的阳性率差异。方法:采用美国Beckman Coulter ACCESS全自动微粒子化学发光免疫分析仪检测1729个乳腺癌转移患者和9262个乳腺癌未转移患者的血清CEA水平。结果:乳腺癌转移患者血清CEA大于5.0为820例,阳性率为:820/1729=47.43%;乳腺癌未转移患者血清CEA大于5.0为837例,其阳性率为:837/9247=9.05%;单纯合并脑、肝、骨、肺、淋巴结转移的患者CEA阳性率分别为56%、48.11%、45.45%、34.26%、18.45%;结论:乳腺癌转移患者血清CEA阳性率高于未转移患者,乳腺癌分别发生脑、肝、骨、肺转移的CEA阳性率间无差别,但都高于乳腺癌淋巴结转移的患者,因此CEA确实可作为乳腺癌病情判断及预后的监测指标。

Objective：To study the correlation between serum CEA level and metastasis of breast cancer,as well as the positive rates difference of CEA among different single organ metastasis in breast cancer.Methods： Serum CEA levels were detected with Beckman Coulter ACCESS chemiluminescent immunoassay in 1729 patients with breast cancer metastasis and 9262 patients without breast cancer metastasis.Results： The positive rate of CEA in the group of metastasis breast cancer patients was 47.43%,while the positive rate of CEA in the group of non-metastasis breast cancer patients was 9.05%.The positive rates of CEA in breast cancer patients complicated by different single organ metastasis were 56% for the brain,48.11% for the liver,45.45% for the bone,34.26% for the lung and 18.45% for the lymph nodes separately.Conclusion： The positive rate of CEA in patients with breast cancer metastasis was higher than that in patients without breast cancer metastasis.There is no significant difference in the positive rate of CEA among all the breast cancer patients with single organ metastasis except the patients with lymph nodes metastasis,while the latter was lower.So CEA can be truly an effective indicator for evaluating the prognosis of breast cancer.