血清CA125和HE4在不同分期的卵巢癌中的表达

Clinical value of serum CA125 and HE4 in different stages of ovarian cancer

目的:回顾性分析血清CA125和HE4在卵巢癌中的表达情况,探讨其在肿瘤不同分期情况下的表达差异。方法:统计分析2011年1月-2011年12月在我院手术治疗的62例卵巢癌血清的CA125和HE4检测结果,其病理结果均为卵巢浆液性、黏液性肿瘤或者混合性肿瘤,计算CA125和HE4在不同分期肿瘤中的表达情况及表达阳性率。结果:CA125在Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期卵巢癌组的阳性率分别为0%、62.5%、84.6%和100%,HE4在Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期卵巢癌组的阳性率分别为0%、25%、61.5%和100%。结论:CA125和HE4在不同分期的卵巢癌血清中的表达有差异。

Objective：To investigate the expression levels of serum CA125 and HE4 in different stages of ovarian cancer.Methods： Of the 62 patients with ovarian cancer from January to December in 2011,the CA125 and HE4 in serum were analyzed.The positive expression percentage of CA125 and HE4 were calculated in different stages of the tumor respectively.Results： The diagnostic positive rates of CA125 and HE4 in ovarian cancer were 0% and 0% in Ⅰstage,62.5% and 25.0% in Ⅱ stage,84.6% and 61.5% in Ⅲ stage,100% and 100% in Ⅳ stage.Conclusion： The serum CA125 and HE4 had different expression levels in different stages of ovarian cancer.