临床鲍曼不动杆菌的耐药性监测与分析

Inspection and analysis of antibiotic resistance of Acinetobacter baumannii

目的:调查3年来鲍曼不动杆菌的检出情况及其对常用抗生素的耐药现状,了解鲍曼不动杆菌的耐药性变迁趋势。方法:统计2009年1月-2011年12月某三甲医院鲍曼不动杆菌的检出及其对临床常用的15种抗生素的药敏情况,并对它们的耐药性及其变迁趋势进行分析。结果:3年来临床标本中鲍曼不动杆菌的检出率分别为7.4%、10.5%和14.0%,对其中11种抗生素的耐药率变化显著(P<0.05),耐5种以上抗生素的鲍曼不动杆菌所占比例分别为19.4%、33.6%和45.9%,呈现逐年明显上升的趋势。结论:鲍曼不动杆菌已成为临床感染重要的病原菌,对常用抗生素的耐药率逐年上升并日趋严重,多重耐药的情况正在进一步恶化。

Objective：To investigate the isolate situation and antibiotic resistance of Acinetobacter baumannii in a ＂AAA＂ hospital in recent three years,so as to know the resistant trend of Acinetobacter baumannii.Methods： From January 2009 to December 2011,isolation rate and resistance rate for 15 antibiotics of Acinetobacter baumannii in some ＂AAA＂ hospital were calculated to analyze the antibiotic resistance and variance trend of Acinetobacter baumannii.Results： The isolate rates of Acinetobacter baumannii were 7.4%,10.5% and 14.0% in 2009,2010 and 2011.The resistant rate variance of eleven antibiotics had significant difference（P0.05）.The proportion of Acinetobacter baumannii resistant to more than five antibiotics were 19.4%,33.6% and 45.9%,showing uplifted trend year by year.Conclusion： Acinetobacter baumannii has become an important pathogen in clinical infection,whose resistance to common-used antibiotics rose year after year,and multi-drug resistance was more and more severe.