5Pu XY, Pan JC, Wang HQ, et al. Characterization of fluoroquinolone -resistant Shigella flexneri in Hangzhou area of China[ J]. J Antimi- crob Chemother, 2009,63 ( 5 ) :917 - 920.
6Cheasty T, Day M, Threlfall EJ. Increasing incidence of resistance to nalidixic acid in shigellas from humans in England and Wales: impli- cations for therapy[J]. Clin Microbiol Infect, 2004-, 10( 11 ) :1033 - 1035.
7Folster JP, Peeic G, Bowen A, et al. Decreased susceptibility to cip- rofloxaein among Shigella isolates in the United States, 2006 to 2009 [ J ]. Antimicrob Agents Chemother, 2011,55 (4) : 1758 - 1760.
8Andres P, Petroni A, Faccone D, et al. Extended -spectrum beta- lactamases in Shigella flexneri from Argentina : first report of TOHO - 1 outside Japan[J]. Int J Antimicrob Agents, 2005,25 (6):501 - 507.
9Kim S, Kim J, Kang Y, et al. Occurrence of extended - spectrum beta - lactamases in members of the genus Shigella in the Republic of Ko- rea [ J ]. J Clin Microbiol, 2004,42 ( 11 ):5264 - 5269.
10Wang M, Tran JH, Jacoby GA,et al. Plasmid - Mediated Quinolone Resistance in Clinical Isolates of Escherichia coli from Shanghai, Chi- na[ J ]. Antimicrob Agents C hemother, 2003,47 (7) :2242 - 2248.
7Jones FT,Chaves SS,Barrett JT,et al.Epidemiology of bacterial enteric infections under active surveillance in Tennessee and Georgia,2000-2002.Tennessee Med,JUL,2004:319-321.
8Gupta A,Polyak SC,Bishop DR,et al.Laboratory-confirmed shigellosis in the United States,1989-2002:epidemiologic trends and patterns.Clin Infect Dis,2004,38:1372-1377.
9Levy SB. Active efflux mechanisms for antibacterial resistance[J].Antimicrob Agents Chemother, 1992, 36(4) :695 - 699.
10Nikaido H. Multidrug efflux pump of Gram- negative bacteria[J]. J Bacteriol, 1996, 178 : 5853 - 5859.
3Z Wang, M Gerstein, M Snyder. RNA-Seq: a revolutionary tool for transcriptomics [ J]. Nat Rev Genet, 2009,10 ( 1 ) : 57- 63.
4E Masse, N Majdalani, S Gottesman. Regulatory roles for small RNAs in bacteria [ J ]. Curr Opin Microbiol, 2003,6 ( 2 ) : 120-124.
5Rahman M,Mauff G,Levy J,et al.Detection of 4-quinolone resis-tance mutation in gyr A gene of Shigella dysenteria type 1 by PCR[J].Antimicrob Agents Chemother,1994,38(10):2488-2491.doi:10.1128/AAC.38.10.2488.
6Azmi IJ,Khajanchi BK,Akter F,et al.Fluoroquinolone RrsistanceMechanisms of Shgella flexneri Isolated in Bangladesh[J].PLo S One,2014,9(7):e102533.doi:10.1371/journal.pone.0102533.
7Ruiz C,Levy SB.Many Chromosomal genes modulate Mar A-mediat-ed multidrug rwsistance in Escherichia coli[J].Antimicrob AgentsChemother,2010,54(5):2125-2134.doi:10.1128/AAC.01420-09.
8Shah AA,Wanq C,Chunq YR,et al.Enhancement of geraniol resis-tance of Escherichia coli by Mar A overexpress[J].Biosci Bioenq,2013,15(3):253-258.doi:10.1016/J.Jbiosc.2012.10.009.
9Alekshun MN,Levy SB.Molecular mechanisms of antibacterial mul-tidrug resistance[J].Cell,2007,128(6):1037-1050.doi:10.1016/j.cell.2007.03.004.
10Ruiz C,Levy SB.Levy Regulation of acr AB expression by cellularmetabolites in Escherichia coli[J].J Antimicrob Chemother,2013,69(2):390-399.doi:10.1093/jac/dkt352.
