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HE4研究进展 被引量:2

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摘要 人附睾分泌蛋白4(Humanepididymisgeneprotein4)是新近提出的肿瘤标志物,它最早由Kirchhoff等[1-2]在1991年发现,从人的附睾远端上皮细胞中克隆到HE4基因的cDNA,有学者认为其功能可能与精子成熟或与天然免疫性有关,但对其具体功能仍不清楚[3],本文对HE4的研究进展做一综述。
机构地区 天津市红桥医院
出处 《陕西医学杂志》 CAS 2012年第12期1676-1677,共2页 Shaanxi Medical Journal
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参考文献14

  • 1Kirchhoff C. Molecular characterization of epididymalproteins[J3. Rev Reprod,1998,3(2) : 86-95.
  • 2Galgano MT, Hampton GM,Frierson HF Jr. Compre-hensive analysis of HE4 expression in normal and malig-nant human tissues[ J]. Mod Pathol,2006,19(6) : 847-853.
  • 3王克义,冷建杭,郑辉,蒋立辉.血清HE4和CA125联合检测在卵巢癌诊断中的价值[J].中国卫生检验杂志,2010,20(5):1139-1140. 被引量:24
  • 4苏彤,刘辉,任清霞,秦燕,徐风亮.HE4、TSGF和CA125联合检测诊断卵巢癌的价值[J].山东医药,2011,51(39):62-64. 被引量:13
  • 5程洪艳,刘亚南,叶雪,昌晓红,成夜霞,崔恒.血清人附睾分泌蛋白4(HE_4)和CA_(125)在卵巢癌患者手术及化疗前后的变化[J].中国妇产科临床杂志,2011,12(3):212-215. 被引量:43
  • 6Anastasi E, Marchei GG,Viggiani V,et al. HE4 : a newpotential early biomarker for the recurrence of ovariancancer[J], Tumour Biol,2010,31 (2) : 113-119.
  • 7Huhtinen K, Suvitie P, Hiissa J, et al. Serum HE4 con-centration differentiates malignant ovarian tumours fromovarian endometriotic cysts[J]. Br J Cancer, 2009,100(8) : 1315-1319.
  • 8Moore RG,Miller CM,Brown AK,et al. Utility oftumor marker HE4 to predict depth of myometrial inva-sion in endometrioid adenocarcinoma of the uterus[J],Gynecol Cancer,2011 .21(7) : 1185-1190.
  • 9Bignotti E, Ragnoli M, Zanotti L, ^ al. Diagnostic and.prognostic impact of serum HE4 detection in endometri-al carcinoma patients [J]. Br J Cancer, 2011, 104 ( 9 ):1418-1425.
  • 10Kamei M, Yamashita S, Tokuishi K^et al. HE4 expres-sion can be associated with lymph node metastases anddisease-free survival in breast cancer [J]. AnticancerRes,2010,30(11): 4779-4783.

二级参考文献38

  • 1梁翠微,杨兵,李小亮,孙达春.CA153、CA125、TSGF联合检测在乳腺癌中的临床意义[J].肿瘤研究与临床,2004,16(5):309-310. 被引量:17
  • 2李山,秦雪,何卫华.血清CA125在卵巢癌诊断中的价值及文献评价[J].中华检验医学杂志,2005,28(2):209-211. 被引量:37
  • 3陈洁晶,吴英松,宁云山,董文其,李明.卵巢癌肿瘤标记物HE4基因的分子克隆与蛋白表达[J].热带医学杂志,2006,6(5):493-495. 被引量:10
  • 4陈颖,赵雨杰,辛彦.cDNA芯片在卵巢癌早诊及临床病理分期中的初步应用探讨[J].中国肿瘤临床,2006,33(23):1338-1341. 被引量:7
  • 5Moore RG, Mc Meekin DS, Brown AK, et al. A novel multiple marker bioassay utillzing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass[ J]. Gynecol Oncol, 2009, 112 (1) :40 -46.
  • 6Moore RG, Brown AK, Miller MC, et al. Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus [ J ]. Gynecol Oncol, 2008, 110 ( 2 ) : 196 - 201.
  • 7Hellstrom I, Raycraft J, Hayden - Ledbetter M, et al. The HFA (WFDC2) protein is a biomarker for ovarian carcinoma [ J ]. Cancer Res, 2003, 63 ( 13 ) : 3695 - 3700.
  • 8Moore RG, Brown AK, Miller MC, et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass[J]. Gynecol Oncol, 2008, 108(2) :405.
  • 9Kirchhoff C, Habben I, Ivell R, et al. A major human epididymis - specific CDNA encodes a protein with sequence homology to extracellu-lar proteinase inhibitors[ J]. Biol Reprod, 1991,45:350-357.
  • 10Moore RG,Mcmeekin DS,Brown AK,et al.A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass.Gynecol Oncol,2009,112:40-46.

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