复方三七纳米颗粒对颅脑损伤大鼠TNF-α、IL-2及IL-6的影响

Effects of Compound Notogin Sengnano Drug on Inflammatory Cytokines TNF-α、IL-2and IL-6 on Brain Injury Rats

目的:探讨复方三七纳米颗粒对颅脑损伤大鼠血清TNF-α、IL-2及IL-6的影响,验证复方三七纳米颗粒对颅脑损伤后机体的保护作用。方法:将96只大鼠随机分为假手术组、创伤模型组、复方三七纳米颗粒组和尼莫地平组,分别予生理盐水、生理盐水、复方三七纳米颗粒、尼莫地平灌胃5d,于造模后第1、3、5d腹主动脉穿刺取血留取标本,观察四组血清TNF-α、IL-2及IL-6含量。每组每个时相点随机选8只完成检测。结果:四组血清TNF-α、IL-2及IL-6比较,时间主效应和干预主效应差异有统计学意义(P<0.05)。结论:复方三七纳米颗粒可降低颅脑损伤大鼠血清中TNF-α、IL-6含量,增加IL-2的表达。

Objective： To explore the compound notogin sengnano drug to head injury rat serum tumor necrosis factor - α, interleukin - 2 and interleukin - 6, the effects of the compound notogin sengnano drug valida- tion of head injury after the body of protection. Methods： 96 mouse randomly divided into the sham group, the trauma model group, notogin sengnano drug group and nimodipine groups, namely to physiological saline, physio- logical saline, notogin sengnano drug, nimodipine irrigation stomach 5d, made in the 1, 3, 5d abdominal aortic blood samples taken puncture enrol your biometrics, observing four groups serum tumor necrosis factor - α, inter leukin -2 and interleukin -6 content. Each group of each phase to choose only 8 random complete detection. Re sults ： Four group serum tumor necrosis factor - α, interleukin - 2 and interleukin and comparison, the effect and time intervention main effects are statistically significant difference （P 〈 0. 05 ）. Conclusion： Notogin sengnano drug can reduce head injury in serum rat tumor necrosis factor - α, interleukin - 6 content and increase interleukin - 2 expression.