雌性激素诱发叙利亚金黄地鼠肿瘤

TUMOR INDUCTION IN SYRIAN GOLDEN HAMSTER BY ESTROGENIC HORMONES

本文用复方己酸孕酮注射液(由己酸孕酮和戊酸雌二醇组成,EP)给雌性和雄性叙利亚金黄地鼠肌肉注射,剂量按体重折合成人的10倍,前13次为每月注射1次,以后每月注射两次,总共注射32次。 结果:EP对雌性地鼠有明显致癌作用,肿瘤发生率74.2％。主要为子宫良性肿瘤,宫颈良性和恶性肿瘤和肾上腺皮质癌。对照组无肿瘤发生,两组肿瘤发生率有非常明显的差异(P<0.005)。 EP处理的雄性地鼠肿瘤发生率为16.7％,主要为肾上腺皮质癌。对照组肿瘤发生率7.7％,为1例肝母细胞瘤,两组肿瘤发生率无明显差异。

Injectio hydroxyprogesteroni composita (Consisting of hydroxyproges-terone caproate and estradiol vaterate in ratio of 50: 1, EP) was injected intramuscularly into female and male Syrian golden hamsters once a month for the first 13 times and then twice a month for foe following 19 times. The results obtained were as follows:(1) The tumor incidence in female hamsters induced by EP was 74.2%. The major types of tumors were benign tumors of uterus, benign and malignant tumors of cervix and adrenal cortex carcinoma. There was a very significant difference (P<0.005) as compared to the incidence in control group (0% ).(2) The tumor incidence in male hamsters was 16.7% . The major type of tumors was adrenal cortex carcinoma. There was no significant difference (P>0.5) as compared to control guoup (7.7% )( 3) According to the results mentioned above, it was suggested that female hamsters are sensitive to EP carcinogenesis but males not .