氯沙坦、阿托伐他汀钙、胺碘酮对心房颤动复发及左心房功能影响的研究

Losartan,Atorvastatin Aalcium,Amiodarone Aecurrence of Atrial Fibrillation and Left Atrial Function Impact Studies

目的观察氯沙坦联用胺碘酮及阿托伐他汀钙在持续性房颤转复后维持窦性心律的作用及对左房功能的影响。方法选择持续性房颤患者48例,药物或食道调博复律后随机分两组:对照组给予胺碘酮0.2g,1次/d;观察组在服胺碘酮的基础上予血管紧张素受体拮抗剂(氯沙坦)50mg,1次/d,阿托伐他汀钙10mg,1次/d,观察复律后第2天及6、12个月后测定左心房功能变化和房颤复发情况。结果随访1年后,观察组和对照组房颤复发比较,差异有统计学意义(P<0.05),而左房内径观察组治疗1年后有显著缩小(P<0.05),对照组上述指标差异无统计学意义(P>0.05)。结论氯沙坦联用胺碘酮及阿托伐他汀钙在持续性房颤转复后维持窦性心律较单用胺碘酮更有效,并可逆转左房扩大。

Objective To observe the effect of Losartan,Amiodarone and Atorvastatin calcium coalescent action on the maintenance of sinus rhythm after conversing the persistent atrial fibrillation,including of the function on left atrium.Methods We selected 48 patients with persistent atrial fibrillation.Then we randomly divided them in two groups after drug or transesophageal atrial pacing and cardioversion.We gave the patients in normal control group 0.2 g Amiodarone once a day.The patients in observational group were given 50 mg angiotensin Ⅱ receptor antagonist（Losartan） once a day,10mg Atorvastatin Calcium once a day on the basis of treating with Amiodarone.In order to observe the changes of left atrial function and recurrence atrial fibrillation on the second day,the sixth month and the 12th month after cardioversion.Results After one year of follow-up,there is a significant difference（P0.05）of comparing the ecurrence atrial fibrillation in the two groups.The left atrial diameter of the patients in observational group emerged significant narrowing（P0.05） after one-year-treated.But no significant difference（P0.05） of those indicators emerged in the normal control group.Conclusion On the maintenance of sinus rhythm after conversing the persistent atrial fibrillation,to combine Losartan with Amiodarone and Atorvastatin Calcium is more effective than to give Amiodarone alone,and it can reverse left room to expand.