急性白血病患者血清对正常人淋巴细胞转化的影响及其与血清铁蛋白浓度的关系

RELATIONSHIP BETWEEN THE EFFECT OF THE SERA IN PATIENTS WITH ACUTE LEUKEMIA ON THE TRANSFORMATION OF NORMAL LYMPHOCYTE AND THE SERUM FERRITIN LEVEL IN THESE PATIENTS

我们利用淋巴细胞转化试验(~3H—Td R渗入法),分别测定20例未治的急性白血病患者血清和12例正常人血清对PHA诱导的正常人淋巴细胞转化的影响。并用放射免疫方法分别测定他们的血清铁蛋白浓度。结果如下: 1、大部分未治的急性白血病患者血清能抑制P H A诱导的正常人淋巴细胞转化。 2、大部分未治的急性白血病患者血清铁蛋白浓度是升高的 3、含有高铁蛋白浓度的急性白亦病患者的血清能抑制P H A诱导的正常人淋巴细胞转化。 根据以上实验结果,我们推测在急性白血病的病程中,异常升高的血清铁蛋白可能是一种使机体细胞免疫功能受损的免疫抑制因子。

We used the tritiated thymidine incorporation test (3H-TdR) to observe the effect of sera of 20 untreated patients with acute leukemia and 12 normal persons on PHA-induced transformation of normal lymphocyte. Their serum ferritin levels were measured by radioimmunoassay. The results are as follws: 1.Most sera of untreated patients with acute leukemia can inhibit the PHA-induced transformation of normal lymphocyte.2.Most untreated patients with acute leukemia have high serum ferritin level.3.Acute leukemia serum with high ferritin level can inhibit the PHA-induced transformation of normal lymphocyte.According to the above results of experiments, we speculate the increased serum ferritin in acute leukemia may be one of the immunosuppressive factors which can impair the cell mediated immunity.