胃癌CEA免疫组化研究及其预后意义

CEA EXPRESSION IN GASTRIC CANCER AND ITS PROGNOSTIC VALUE: AN IMMUNOHISTOCHEMICAL STUDY

本文采用亲和素——生物素酶复合物(ABC)免疫组织化学技术,对84例胃癌根治手术切除标本进行CEA研究,发现在有淋巴结转移组和肿瘤浸润浆膜组,CEA(+)率明显高于无淋巴结转移组及未浸润浆膜组,CEA表现与肿瘤分化无明显关系。按PTNM分期,Ⅲ期病人CEA(+)占82％,而Ⅰ及Ⅱ期仅占44％。随访表明,CEA(-)组5年生存率明显高于CEA(+)组。实验结果提示:CEA(+)肿瘤有转移和浸润倾向,肿瘤期较晚,免疫组化CEA染色对胃癌的预后判断有重要价值。

The expression of carcinoembryonic antigen (CEA) in gastric cancer specimens obtained from 84 patients was studied by using an avidin-biotin peroxidase complex (ABC) method. The positivity of CEA was significantly higher in the patients' with secosal invasion and lymph node metastasis than that in the patients without. However, the CEA expression in cancer had no correlation with the degree of tumor differentiation in this study, According to the pTNM classfication, most (82%) of the stage 111 patients showed CEA(+), and only 44% of stage Ⅰ and Ⅱ patients was CEA (+). The followup showed that the 5-year survival rate of CEA(-) group was significantly higher than that of CEA (+) group. The present data suffest that CEA(+) tumor is more agressive and may indicate the tumor in an advanced stage. Immunohistochemical stainning of CEA in tumor tissue is of value for the prognosis of gastric cancer.