钙网织蛋白与肿瘤

Calreticulin and tumor

钙网蛋白是一种多功能的内质网Ca2+结合蛋白,是未折叠蛋白反应的关键分子,参与调节钙平衡、蛋白质的折叠和加工、抗原提呈、细胞分化与凋亡等多种生物学功能。近年的研究表明,钙网蛋白在多种肿瘤中特异性表达,与肿瘤的发生、发展、诊断、预后以及治疗密切相关。本文对钙网蛋白与肿瘤关系的研究进展作一综述。

Calreticulin （CRT） is a multifunctional Ca2＋-binding which participates in the regulation of intracellular presentation, cellular differentiation, apoptosis, and protein and an effector of unfolded protein response （UPR）, Ca2＋ homeostasis, protein folding and processing, antigen so on. For the past few years, it is reported that the specific overexpression of CRT in various tumor tissues is closely related to the occurrence, development, diagnosis, prognosis and therapy for tumor. This review summarizes the relation between CRT and tumor.