脓毒症中骨髓来源的抑制细胞的研究进展

Roles of myeloid-derived suppressor cells in sepsis

骨髓来源的抑制细胞是由一群同时表达表面分子GR-1和CD11b的非成熟骨髓细胞组成,对天然免疫和获得性免疫具有显著抑制作用。尽管骨髓来源的抑制细胞最早出现在肿瘤研究中,然而已有大量研究显示它与创伤、炎症、自身免疫性疾病以及脓毒症有密切关系。本文就目前骨髓来源的抑制细胞在脓毒症中作用的研究进展及其用于脓毒症治疗的前景进行论述。

Myeloid-derived suppressor cells are a heterogenous population of immature myeloid cells characterized by surface expression of myeloid lineage markers GR-1 and CD1 lb, and by their remarkable ability to suppress T-cell responses and innate immunity. Although myeloid-derived suppressor cells were originally studied and are best known for their role in tumor immune evasion and promotion of metastasis, much attention to their roles in other pathological conditions such as trauma, inflammation, autoimmune disease, and sepsis as well. This review provides a comprehensive summary of the recent literatures on the roles of myeloid-derived suppressor cells and the potential therapeutic benefits targeting them in sepsis.