患者淋巴细胞计数与外周血组份间关系的研究

Relationship between T lymphocytes counts and peripheral blood components in HIV/AIDS patients

目的分析HIV/AIDS患者外周血T淋巴细胞计数和血常规检测结果。方法收集78例HIV/AIDS患者(HIV/AIDS组)、55例健康体检人员(健康对照组)的抗凝血,用流式细胞仪技术检测外周血CD4+T及CD8+T淋巴细胞,全自动血细胞分析仪检测血常规。结果 78例患者中有71.79%(56/78)CD4+T淋巴细胞数<200个/μl,98.72%的HIV/AIDS患者CD4+/CD8+比值<0.8,其中75.64%(59/78)患者4/8介于0.1～0.5之间。CD4+、CD8+、CD3+、CD4/CD8、WBC、LYMPH六个项目HIV/AIDS组与健康对照组比较差异均有统计学意义(P<0.05),NEUT、%NEUT及%LYMPH三个项目两组间比较差异无统计学意义(P>0.05)。结论 HIV/AIDS患者在发病过程中与CD4+、CD8+、CD3+、CD4+/CD8+及LYMPH密切相关,建议HIV感染者尽早进行医学咨询并做CD4+、CD8+和血常规的检测,以了解病情的进展及进行抗病毒治疗。

Objective To explore the relationship between peripheral T lymphocyte count and blood test results among HIV/AIDS patients.Methods Anticoagulant were collected from 78 cases of HIV/AIDS（HIV/AIDS group） and 55 cases of healthy volunteers（healthy control group）,CD4＋T and CD8＋T lymphocytes in peripheral blood by flow cytometry were detected,while detected blood cells routine testing were by automatic hematology analyzer.Results 71.79%（56/78） in 78 patients CD4＋T lymphocyte count were 200 cells /μl,98.72% patients CD4＋/CD8＋were0.8,among which 75.64%（59/78） patients CD4/CD8 between 0.1~0.5.Those six projects CD4＋,CD8＋,CD3＋,CD4/CD8,WBC and LYMPH both had statistics significance when HIV/AIDS group compared with control group.While those three projects NEUT,%NEUT and %LYMPH had no statistics significance.Conclusion It is closely related to CD4＋,CD8＋,CD3＋,CD4＋/CD8＋ and LYMPH in the disease process of HIV/AIDS patients.CD4＋,CD8＋,blood cells routine testing are detected early to understand the progression of the disease and antiviral therapy time.