左氧氟沙星联合舒血宁治疗矽肺合并肺部感染疗效观察

Efficacy of levofloxacin combined with Shuxuening injection in treatment of senile silicosis patients complicated with pulmonary infection

目的探讨左氧氟沙星联合舒血宁治疗老年人矽肺合并肺部感染的临床疗效。方法 92例老年人矽肺合并肺部感染患者,随机分为治疗组和对照组;对照组予抗菌素(左氧氟沙星)、吸氧、化痰、止咳、平喘及调节水电解质平衡等治疗,治疗组在对照组基础上配合舒血宁注射液治疗,对两组临床表现恢复正常的时间及治疗效果分别进行t检验和χ2检验。结果两组在热、咳、痰、喘、胸闷、胸痛、紫绀、呼吸音、肺部啰音、肺部阴影等表现消失和血象恢复正常所需时间比较,治疗组明显短于对照组,差异有统计学意义(P<0.05或P<0.01);治疗组和对照组的总有效率分别为82.61%和69.57%,两者比较差异有统计学意义(P<0.05)。结论左氧氟沙星联合舒血宁治疗老年人矽肺合并肺部感染的疗效显著,值得在临床上推广应用。

Objective To investigate the efficacy of levofloxacin combined with Shuxuening Injection in treatment of senile silicosis patients complicated with pulmonary infection.Methods The 92 elderly silicosis cases complicated with pulmonary infection were randomly divided into treatment group and controlled group;The control group was treated with antibiotics（levofloxacin） and symptomatic therapy,and the treatment one was treated with Shuxuening injection on the basis of the control group,the effects in two groups were analyzed with t-test and Chi square test.Results The days required for disappearance of fever,cough,phlegm,shortness of breath,cyanosis,chest tightness,chest pain and respiratory sounds,pulmonary rale,pulmonary shadow and the blood return to normal in two groups were recorded and compared.The time of blood returning to normal in patients of treatment group was significantly shorter than that of the control group,showing significant difference（P0.05 or P0.01）;The total effective rates in the treatment group and control group were 82.61% and 69.57%,qalso showing significant difference（P0.05）.Conclusion The efficacy of evofloxacin combined with Shuxuening Injection is marked and worthy to be popularized for clinical application.