免疫治疗对特应性皮炎患者血清白细胞介素-4水平的影响

Effect of immunotherapy on serum interleukin-4 in patients with atopic dermatitis

目的研究特异性免疫治疗对特应性皮炎患者血清白介素-4的影响。方法在符合特应性皮炎诊断的43例患者进行气传变应原皮内试验及外周血嗜酸粒细胞(EOS)、血清总IgE(TIgE)、白细胞介素-4(IL-4)水平检测,对血清IL-4高于正常且皮试结果(++)及以上的31例患者进行皮下注射特异性免疫治疗,并于特异性免疫治疗后1年及2年后再进行血清IL-4检测,对患者在治疗前后及不同治疗阶段血清IL-4值进行比较。结果 AD患者在特异性免疫治疗前表现为血清高IL-4值(429.19±79.04)pg/L,经过1～2年的特异性免疫治疗后IL-4水平分别降低为(167.09±52.90)pg/L和(101.46±44.15)pg/L。治疗前、治疗1年后与2年后IL-4值比较差异有统计学意义(F=254.32和F=454.23,P均<0.01) 结论特异性免疫治疗可降低AD患者血清IL-4水平。

Objective To study the impact of specific immunotherapy（SIT） on IL-4 levels in atopic dermatitis（AD）.Methods The 43 patients with atopic dermatitis diagnosed by using airborne allergen test,original intradermal test and detection of peripheral blood eosinophils（EOS）,serum total IgE（TIgE）,serum interleukin-4（IL-4）.The 31 cases with serum IL-4 levels higher than normal and the skin test results（＋＋）,were treated with subcutaneous injection of specific immunotherapy.The serum IL-4 levels before treatment,a yer after treatment and 2 years after treatment were tested and compared.Results The serum IL-4 levels in the ptients before treatment with STI,a year after treatment with STI and 2 years after treatment were 429.19±79.04）pg/L,（167.09±52.90）pg/L and（101.46±44.15）pg/L,all showing significant statistical diferences（（F=254.32 and F=454.23,P0.01）.Conclusion Specific immunotherapy can reduce the levels of IL-4 of AD patients.