男性肥胖隐性高血压患者血清同型半胱氨酸及高敏C反应蛋白水平分析

Level of Serum Homocysteine and High-sensitivity C-reactive Protein in Male Obese Patients with Masked Hypertension

目的探讨肥胖伴隐性高血压(MH)患者血清同型半胱氨酸(Hcy)及高敏C反应蛋白(hs-CRP)水平的变化及临床意义。方法选取诊所血压(CBP)正常的肥胖患者78例,均行24h动态血压(ABP)检查,按日间血压检测结果,将肥胖患者分为单纯肥胖组(肥胖组)43例和肥胖伴MH组(MH组)35例;同时选取30例体重正常的健康体检者作为对照。对比分析3组血清Hcy、hs-CRP水平。结果肥胖组MH发病率44.87%(35/78),显著高于对照组的11.43%(P<0.01);肥胖伴MH组的24h平均收缩压、舒张压(24hSB、24hDBP),日、夜平均收缩压(dSBP、dDBP)均明显高于单纯肥胖组和对照组,其血清Hcy、hs-CRP水平也显著高于单纯肥胖组(P<0.05)和对照组(P<0.01);单纯肥胖组血清Hcy、hs-CRP水平与对照组比较无统计学意义。结论肥胖患者MH发病率显著高于对照组,其血清Hcy、hs-CRP水平也明显升高。提示血清Hcy、hs-CRP可能参与了肥胖患者并发高血压的发生、发展过程。

Objective To study the clinical significance of the serum homocysteine（Hcy） and high-sensitivity C-reactive protein（hs-CRP） in obese patients with masked hypertension（MH）.Methods Seventy-eight obese patients with normal clinic blood pressure（CBP） were divided into two groups according to the result of daytime blood pressure of ambulatory blood pressure monitoring（ABPM）：Obesity with MH（n=35）,obesity（n=43）.Thirty healthy subjects with normal weight were selected as controls.The Hcy and hs-CRP were measured and assessed in three groups.Results The 24 h SBP,4 h DBP,dSBP,and dDBP in obesity with MH group were significantly higher than that in the other two groups（P0.01）.The Hcy and hs-CRP in obesity with MH group were also higher than in obesity group and control group（P0.05 or P0.01）.The Hcy and hs-CRP in obesity were higher than that in control group,but there were no significant difference.Conclusion There were high level of the Hcy and hs-CRP in obese patients,especially in obesity with MH.The Hcy and hs-CRP might be involved the occurrence and development process of hypertension in obese patients.