前列地尔注射液治疗缺血性脑卒中的疗效和安全性Meta分析

Effect and Safety of Alprostadil Injection on Ischemic Stroke:A Meta-analysis

目的评价前列地尔注射液治疗缺血性脑卒中的临床疗效和安全性。方法检索已在维普、CNKI数据库公开发表的、以前列地尔注射液为干预措施、中药注射液(除丹参注射液外)为对照治疗缺血性脑卒中的随机对照试验(RCT),评价纳入文献的方法质量学,提取有效数据,采用Cochrane协作网提供的RevMan5.1软件进行Meta分析。结果共纳入9篇文献,研究对象共633例,试验组324例,对照组309例。Meta分析结果,前列地尔注射液治疗缺血性脑卒中的有效率高于中药注射液(P<0.000 01),OR及其95%置信区间(CI)为5.24(3.12,8.80);两组日常生活能力评分差异无统计学意义(P=0.26),加权均数差(WMD)及其95%CI为-0.13(-0.37,0.10)。两组不良反应差异有统计学意义(P=0.01),OR及其95%CI为4.04(1.33,12.28)。结论前列地尔注射液治疗缺血性脑卒中患者的有效率高于中药注射液。

Objective To investigate the efficacy of alprostadil injection for treatment of ischemic stroke.Methods The electronic databases of Weipu and CNKI were searched to collect the published randomized controlled trials（RCT） with interventions of alprostadil injection for ischemic stroke.Results Nine papers of literature were adopted,including 633 patients.Three hundreds and twenty four patients in treatment group were treated with alprostadil injection and the others treated with traditional Chinese medicine（but single parameter） were in control group.Meta analysis showed that the patients in alprostadil injection group were better than that in control group.After treatment,the clinical curative rate of 95% CI was 5.24（3.12,8.80）.There was no difference in daily life ability score between treatment group and control group（P=0.26）,weighted mean difference（WMD） and 95% CI were-0.13（-0.37,0.10）.Conclusion Alprostadil injection was more effective than traditional Chinese medicine for treatment of ischemic stroke.