期刊文献+

重组人脑利钠肽治疗心力衰竭疗效观察 被引量:11

下载PDF
导出
摘要 目的观察重组人脑利钠肽治疗心力衰竭的临床疗效。方法将入选的心力衰竭患者随机分为治疗组和对照组,对照组给予常规药物治疗,治疗组在常规药物治疗基础上加用重组人脑利钠肽治疗。结果两组治疗后较治疗前临床症状、射血分数、血浆N末端B型利钠肽原(NT-proBNP)以及6min步行试验均有改善(P<0.05)。治疗后两组间相比,治疗组患者临床症状、射血分数、血浆NT-proBNP以及6min步行试验改善明显(P<0.05)。结论重组人脑利钠肽可有效治疗心力衰竭,且安全性高,无明显不良反应。
作者 李永才
出处 《中西医结合心脑血管病杂志》 2012年第12期1512-1513,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
  • 相关文献

参考文献10

  • 1刘国仗,吴宁,胡大一,陶萍,诸骏仁,郭林妮,郭静萱,游凯.心血管药物临床试验评价方法的建议[J].中华心血管病杂志,1998,26(6):405-413. 被引量:472
  • 2Mccullough PA. Clinical applicatiions of B - type natriuretic peptide levels in the care of cardiovascular patients[J]. Minerva Cardioan giol,2004,52 :479 489.
  • 3Sucloh T, Kangawa K, Minamino N, et al. A natriuretic peptide in porcine brain[J]. Nature, 1998,332 78 - 81.
  • 4曹雅旻,胡大一,闫丽.急性冠状动脉综合征严重程度与血浆氨基酸N末端脑钠肽原浓度相关性的研究[J].中华心血管病杂志,2005,33(10):899-902. 被引量:60
  • 5Hunt SA,Abraham WT,Chin MH,et al. ACC/AHA 2005 Guide line Update for the Diagnosis and Management o{ Chronic Heart Failure in the Adult:A report of the American College of Cardiolo- gy/American Heart Association 'Task Force on Practice Guidelines [J]. Circulation, 2005,112 e154 -- 235.
  • 6王文武,张真路.B型钠尿肽在心力衰竭分级及预后中的应用[J].微循环学杂志,2006,16(4):43-45. 被引量:13
  • 7Abraham WT, Lowes BD, Ferguson DA, et al. Systemic hemody namic, neurohormona 1 and renal excretory effects of asteady- state infusion of human brain natriuretie peptide in patients with decompensated chronic heart failure[J]. J Card Fail, 1998,4:37 - 44.
  • 8Mills RM, LeJemtel TH, Horton DP, et al. Sustained hemodynamic effects of an infusion of nesiritide (human b- type natriuretic pep tide) in heart failure A randomized, double - blind, placebo - con- trolled clinical trial Natrecor Study Group[J]. J Am Coil Cardio, 1999,34:155 - 162.
  • 9Colucci WS,Elkayam E, Horton DP,et al. Intravenousnesiritide, a natriuretic peptide,in the treatment of deeompensated heart failure[J]. N Engl J Med,2000,343:246- 253.
  • 10Publication Committee for the VMAC Investigators. Intravenous nesiritide vs nitroglycerin {or treatment of decompented conges- tive heart failure: A randomized controlled trial[J]. J AMA,2002, 287(12) :1531 - 1540.

二级参考文献29

  • 1陈卫中,倪宗瓒,潘晓平,刘元元,夏彦.用ROC曲线确定最佳临界点和可疑值范围[J].现代预防医学,2005,32(7):729-731. 被引量:208
  • 2团体著者,中华心血管病杂志,1996年,24卷,328页
  • 3Cheung BMY, Kumana CR. Nariuretic peptides-relevance in cardiac disease. JAMA, 1998,280:1983-1984.
  • 4Etsuo M, Hirofumi Y, Michihiro Y, et al. Increased plamsma levels of brain natriuritic peptide in patients with acute myocardial infarction. Circulation, 1993,88:82-91.
  • 5Dicstein K. Natriuretic peptides in detection of heart failure. Lancet, 1998,35: 3-4.
  • 6Clerico A, Iervasi G, Chicca M, et al. Circulating levels of cardiac natriuretic peptides (ANP and BNP) measured by highly sensitive and specific immunoradiometric assays in normal subjects and in patients with different degrees of heart failure. J Endocrinol Invest, 1998,21: 170-179.
  • 7Maisel A. B-type natriuretic levels: a potential novel "White count" for congestive heart failure. J Cardiac Fail, 2001, 7: 183-193.
  • 8Brandt RR, Burnett Jr. Humoral control of the kidney during congestive heart failure: role of cardiac natriuretic peptides and angiotensin II. In: Poole-Wilson PA, Colucci WS, Massie BM, eds. Heart Failure. New York: Churchill Livingstone, 1997.143-154.
  • 9Mair J, Hammerer-lercher A, Puschendorf B. The impact of cardiac natriuretic peptide determination on the diagnosis and management of heart failure. Clin Chem Lab Med, 2001, 39:571-588.
  • 10Talwar S, Squire IB, Downie PF, et al. Plasma N terminal pro-brain natriuretic peptide and cardiotrophin 1 are raised in unstable angina. Heart, 2000,84:421-424.

共引文献540

同被引文献70

引证文献11

二级引证文献183

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部