期刊文献+

早期辛伐他汀干预对急性心肌梗死患者氧化型低密度脂蛋白的影响 被引量:3

下载PDF
导出
摘要 目的观察早期他汀类药物干预对急性心肌梗死(AMI)早期血浆氧化低密度脂蛋白(oxLDL)的影响,以探讨AMI早期应用他汀类药物的必要性。方法所有入选患者均于干预前和治疗后5d抽取静脉血检测oxLDL、血脂等生化指标,分析辛伐他汀干预前后oxLDL的统计学意义。结果 20mg/d、40mg/d辛伐他汀组干预后oxLDL低于干预前(P<0.05),与对照组干预后比较,血浆oxLDL水平显著降低(P<0.05或P<0.01),40mg/d辛伐他汀组与20mg/d辛伐他汀组干预后oxLDL相比有统计学意义(P<0.05)。结论 ACS早期他汀类药物治疗具有抗oxLDL等调脂外效应,且存在剂量依赖性。
作者 刘建平
出处 《中西医结合心脑血管病杂志》 2012年第12期1525-1526,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
  • 相关文献

参考文献3

二级参考文献12

  • 1Dupuis J, Tardif J C, Cernacek P, et al. Theroux cholesterol reduction rapidly improves endothelial function of the RECIFE (Reduction of cholesterol in ische-mial and function of the endothelium) trial. Circulation,1999,99: 3227- 3233.
  • 2The Long-term Intervention with Pravastatin in Ischaemic Disease(LIPID) study group. Prevention of cardiovascular events and a broad range of initial cholesterol levels. N EnglJ Med, 1998,339:1349-1357.
  • 3Pederson J R, Olsson A G, Faergeman V, et al. Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S). Circulation, 1998,97:1453-1460.
  • 4FlakerG C, Warnica J W, Sacks F M,et al. For the Cholesterol and Recurrent Event(CARE) investigators.Pravastatin prevents clinical events in revascularized patients with average cholesterol concentrations. J Am Coll Cardiol, 1999,34:106- 112.
  • 5Schwartz G G, Olsson A G, Ezekowitz M D, et al.Effects of atorvastatin on early recurrent ische mic events in acute coronary syndrome. The MIRACL study: A randomized controlled trial. JAMA, 2001,285:1711-1718.
  • 6Maron D J, Fazio S, Linton M F. Current perspectives on statins. Circulation, 2000,101: 207- 213.
  • 7Bustos C, Hernandez-Presa M A, Ortego M, et al.HMG-GoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis. J Am Coll Cardiol, 1998,32:2057-2064.
  • 8Laufs U, Liao J K. Post-transcriptional regulation of endothelial nitric oxide synthasc mRNA stability by Rho GTPase. J Biol Chem, 1998,273:24266-24271.
  • 9Williams J K, Sukova G K, Herrington D M, et al.Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys. J Am Coll Cardiol, 1998,31: 684- 691.
  • 10Rose.,RS,胡予.他汀类药物的抗粥样血栓特性对心血管事件减少的意义[J].美国医学会杂志(中文版),1999,18(3):110-115. 被引量:20

共引文献906

同被引文献28

引证文献3

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部