低分子肝素钙治疗早发型重度子痫前期患者临床疗效观察

The Clinical Curative Effect Observation on Low Molecular Weight Heparin Calcium in the Treatment of Early Onset Severe Preeclampsia

目的探讨低分子肝素钙治疗早发型重度子痫前期对母体的影响。方法选取孕龄26～34周重度子痫前期患者82例,按照随机数表单盲法分为观察组和对照组各41例,观察组在常规治疗的基础上加用低分子肝素钙,对比两组血压、血脂、24 h尿蛋白定量、凝血纤溶功能、并发症的差异。结果观察组平均动脉压、24 h尿蛋白、血脂三酰甘油、总胆固醇、低密度脂蛋白、载脂蛋白B均下降,高密度脂蛋白、载脂蛋白A增加,两组间比较差异有统计学意义(P<0.05);凝血功能无改变,纤溶活性降低,产后出血无增加,并发症降低。结论论早发型重度子痫前期患者的病情重,异常围生儿结局发生率高,低分子肝素钙作为基本治疗药物之一安全有效。

Objective To evaluate the effect of low molecular weight heparin calcium on the pregnant women in treatment of early onset severe preeclampsia.Methods 82 patients of 26-34 gestational weeks with severe preeclampsia were selected and divided into observation group and control group randomly.The patients in observation group were treated with additional low molecular weight heparin calcium on the basis of conventional treatment.The differences of indexes including blood pressure,blood lipids,24-hour urinary protein count,coagulation and fibrinolytic function,complications in the two groups were compared.Results In observation group,the MAP,24-hour urinary protein count,TG,TC,LDL and apo-B decreased,HDL and apo-A increased,there were significant differences between the two groups（P0.05）;coagulation function didn′t change,the fibrinolytic activity decreased,the amount of postpartum hemorrhage did not increase,the incidences of complications decreased.Conclusion Clinical symptoms of early onset severe preeclampsia are severe with a higher incidence of abnormal prenatal outcomes,and low molecular weight heparin calcium is safe and effective as one of the basic drugs.